African trypanosomiasis historical perspective: Difference between revisions

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{{African trypanosomiasis}}
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==Overview==
African trypanosomiasis has been present in Africa for thousands of years. In 1903, David Bruce identified the [[vector]] of causative agent. In 1910, the differentiation between the [[subspecies]] of the [[protozoa]] was established.
 
==Historical Perspective==
*In 1841, Valentin, a professor of [[physiology]], discovered a trypanosome-like [[flagellate]] for the first time in the [[blood]] of a trout.<ref name="pmid15145378">{{cite journal |vauthors=Cox FE |title=History of sleeping sickness (African trypanosomiasis) |journal=Infect. Dis. Clin. North Am. |volume=18 |issue=2 |pages=231–45 |year=2004 |pmid=15145378 |doi=10.1016/j.idc.2004.01.004 |url=}}</ref>
*In 1843, Gruby gave a detailed description of [[trypanosomes]] based on the work done independently by Gluge and Mayer in the [[blood]] of frogs.
*In 1891, Nepveu identified [[trypanosomes]] for the first time in human [[blood]].
*In 1898, Brault suggested [[trypanosomes]] as the cause of [[sleeping sickness]].
*In 1901, Forde and Dutton described [[Trypanosoma brucei gambiense|''Trypanosoma brucei gambiense'']] in human [[blood]] for the first time.
*In 1902, the First and Second [[Sleeping Sickness]] Commissions led by Low and Bruce were conducted in Uganda.
*In 1902, Castellani identified [[trypanosomes]] in the [[cerebrospinal fluid]] of patients suffering from [[sleeping sickness]] for the first time.
*In 1903, David Bruce recognized the [[tsetse fly]] as the [[arthropod]] [[Vector (biology)|vector]].
*In 1905, Bruce suggested that [[Tsetse fly|tsetse flies]] transmit trypanosomes mechanically.
*In 1909, Kleine demonstrated the cyclical transmission of trypanosomes in [[Tsetse fly|tsetse flies.]]
*In 1910, Stevens and Fantham identified [[Trypanosoma brucei rhodesiense|''Trypanosoma brucei rhodesiens''e]] as the cause of acute [[sleeping sickness]].
*In 1914, Ritz described the [[antigenic variation]] of [[trypanosomes]].
*In 1969, Vickerman described the coat of [[trypanosomes]] as the source of [[antigenic variation]].


==Overview==
== Landmark Events in Treatment Strategies ==
* In 1902, Laveran and Mesnil discovered that sodium arsenite can be used to kill [[trypanosomes]].
* In 1945, [[DDT]] was used for the first time in controlling [[Tsetse fly|tsetse flies]].
* In 1949, [[melarsoprol]] was used for the first time as an anti-trypanosome drug.
* In 1992, [[eflornithine]] was used for the treatment of human [[Sleeping sickness (patient information)|sleeping sickness]].


==References==
==References==
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Latest revision as of 20:19, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Pilar Almonacid, Aditya Ganti M.B.B.S. [2]

Overview

African trypanosomiasis has been present in Africa for thousands of years. In 1903, David Bruce identified the vector of causative agent. In 1910, the differentiation between the subspecies of the protozoa was established.

Historical Perspective

Landmark Events in Treatment Strategies

References

  1. Cox FE (2004). "History of sleeping sickness (African trypanosomiasis)". Infect. Dis. Clin. North Am. 18 (2): 231–45. doi:10.1016/j.idc.2004.01.004. PMID 15145378.