Adult T-cell leukemia epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
The majority of adult T-cell leukemia cases are reported in Japan, the Caribbean, South America, and Africa. In southern Japan, the age-adjusted incidence rate of adult T-cell leukemia is approximately 6.6 per 100,000 individuals. The incidence of adult T-cell leukemia increases with age; the median age at diagnosis is 57 years. Females are more commonly affected with adult T-cell leukemia than males. The female | The majority of adult T-cell leukemia cases are reported in Japan, the Caribbean, South America, and Africa. In southern Japan, the age-adjusted incidence rate of adult T-cell leukemia is approximately 6.6 per 100,000 individuals. The incidence of adult T-cell leukemia increases with age; the median age at diagnosis is 57 years. Females are more commonly affected with adult T-cell leukemia than males. Males are more commonly affected with adult T-cell leukemia than females. The male to female ratio is approximately 1.4 to 1. Adult T-cell leukemia usually affects individuals of the African American, Latin american, and Asian race. Caucasian individuals are less likely to develop adult T-cell leukemia.<ref name="pmid25219595">{{cite journal| author=Satake M, Yamada Y, Atogami S, Yamaguchi K| title=The incidence of adult T-cell leukemia/lymphoma among human T-lymphotropic virus type 1 carriers in Japan. | journal=Leuk Lymphoma | year= 2015 | volume= 56 | issue= 6 | pages= 1806-12 | pmid=25219595 | doi=10.3109/10428194.2014.964700 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25219595 }} </ref><ref name="pmid22973265">{{cite journal| author=Iwanaga M, Watanabe T, Yamaguchi K| title=Adult T-cell leukemia: a review of epidemiological evidence. | journal=Front Microbiol | year= 2012 | volume= 3 | issue= | pages= 322 | pmid=22973265 | doi=10.3389/fmicb.2012.00322 | pmc=PMC3437524 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22973265 }} </ref> | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
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:* The median age at diagnosis in Central America is 40 years | :* The median age at diagnosis in Central America is 40 years | ||
===Gender=== | ===Gender=== | ||
* | * Males are more commonly affected with adult T-cell leukemia than females. The male to female ratio is approximately 1.4 to 1. | ||
* Females are more commonly affected with HTLV infection than males. | * Females are more commonly affected with HTLV infection than males. | ||
* However, the risk of adult T-cell leukemia development among HTLV male carriers is five fold higher than the risk of adult T-cell leukemia development among HTLV female carriers. | * However, the risk of adult T-cell leukemia development among HTLV male carriers is five fold higher than the risk of adult T-cell leukemia development among HTLV female carriers. | ||
Revision as of 15:49, 24 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
The majority of adult T-cell leukemia cases are reported in Japan, the Caribbean, South America, and Africa. In southern Japan, the age-adjusted incidence rate of adult T-cell leukemia is approximately 6.6 per 100,000 individuals. The incidence of adult T-cell leukemia increases with age; the median age at diagnosis is 57 years. Females are more commonly affected with adult T-cell leukemia than males. Males are more commonly affected with adult T-cell leukemia than females. The male to female ratio is approximately 1.4 to 1. Adult T-cell leukemia usually affects individuals of the African American, Latin american, and Asian race. Caucasian individuals are less likely to develop adult T-cell leukemia.[1][2]
Epidemiology and Demographics
Prevalence
- In the US, adult T-cell leukemia is considered a rare disease that mainly tends to affect African American intravenous drug abusers.
- The majority of adult T-cell leukemia cases are reported in Japan, the Caribbean, South America, and Africa.
Incidence
- In southern Japan, the age-adjusted incidence rate of adult T-cell leukemia is approximately 6.6 per 100,000 individuals.
Age
- The incidence of adult T-cell leukemia increases with age; the median age at diagnosis is 57 years.
- The age of onset for adult T-cell leukemia differs across geographical regions, such as:
- The median age at diagnosis in Japan is 60 years
- The median age at diagnosis in Central America is 40 years
Gender
- Males are more commonly affected with adult T-cell leukemia than females. The male to female ratio is approximately 1.4 to 1.
- Females are more commonly affected with HTLV infection than males.
- However, the risk of adult T-cell leukemia development among HTLV male carriers is five fold higher than the risk of adult T-cell leukemia development among HTLV female carriers.
Race
- Adult T-cell leukemia usually affects individuals of the African American, Latin american, and Asian race. Caucasian individuals are less likely to develop adult T-cell leukemia.
References
- ↑ Satake M, Yamada Y, Atogami S, Yamaguchi K (2015). "The incidence of adult T-cell leukemia/lymphoma among human T-lymphotropic virus type 1 carriers in Japan". Leuk Lymphoma. 56 (6): 1806–12. doi:10.3109/10428194.2014.964700. PMID 25219595.
- ↑ Iwanaga M, Watanabe T, Yamaguchi K (2012). "Adult T-cell leukemia: a review of epidemiological evidence". Front Microbiol. 3: 322. doi:10.3389/fmicb.2012.00322. PMC 3437524. PMID 22973265.