Adenosylhomocysteinase
| S-adenosylhomocysteine hydrolase | |
|---|---|
| File:1li4.jpg SAH hydrolase tetramer, Human | |
| Identifiers | |
| Symbol | AHCY |
| Entrez | 191 |
| HUGO | 343 |
| OMIM | 180960 |
| RefSeq | NM_000687 |
| UniProt | P23526 |
| Other data | |
| EC number | 3.3.1.1 |
| Locus | Chr. 20 q11.22 |
Adenosylhomocysteinase (EC 3.3.1.1, S-adenosylhomocysteine synthase, S-adenosylhomocysteine hydrolase, adenosylhomocysteine hydrolase, S-adenosylhomocysteinase, SAHase, AdoHcyase) is an enzyme that converts S-adenosylhomocysteine to homocysteine and adenosine.[1][2] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-homocysteine + H2O <math>\rightleftharpoons</math> L-homocysteine + adenosine
The enzyme contains one tightly bound NAD+ per subunit.
References
- ↑ de la Haba, G.; Cantoni, G.L. (1959). "The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine". J. Biol. Chem. 234 (3): 603–608. PMID 13641268.
- ↑ Palmer, J.L.; Abeles, R.H. (1979). "The mechanism of action of S-adenosylhomocysteinase". J. Biol. Chem. 254 (4): 1217–1226. PMID 762125.
External links
- Adenosylhomocysteinase at the US National Library of Medicine Medical Subject Headings (MeSH)