Adenocarcinoma of the lung natural history, complications, and prognosis
Adenocarcinoma of the Lung Microchapters |
Differentiating Adenocarcinoma of the Lung from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Natural History
- The majority of lung cancers present with advanced disease because the symptoms tend to occur later in the course of the disease.[1]
- The patient experiences non-specific symptoms such as cough, hemoptysis, dyspnea, chest pain, dysphonia, dysphagia, lack of appetite, weight loss, and fatigue from 3 weeks to 3 months before seeking medical attention.
- While of duration of symptoms, the tumor cell may double 20 times.[1]
- In more advanced disease, the tumor may spread to other organs such as the spinal cord, brain, and bone.
- These patients may develop symptoms such as leg weakness, paresthesias, bladder dysfunction, seizures, hemiplegia, cranial nerve palsies, confusion , personality changes, skeletal pain, and pleuritic pain.[1]
- Once the cancer spreads to the other organs, it is most likely fatal.
Prognosis
Non–small cell lung cancer survival rate by stage[2]
Stage | 5-year survival rate |
---|---|
IA | 49% |
IB | 45% |
IIA | 30% |
IIB | 31% |
IIIA | 14% |
IIIB | 5% |
IV | 1% |
References
- ↑ 1.0 1.1 1.2 Leary, A (2012). Lung cancer a multidisciplinary approach. Chichester, West Sussex, UK Ames, Iowa: Wiley-Blackwell. ISBN 9781405180757.
- ↑ Lung cancer. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/lung/prognosis-and-survival/survival-statistics/?region=ab