Adenocarcinoma of the lung classification: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Adenocarcinoma of the lung}} | {{Adenocarcinoma of the lung}} | ||
{{CMG}}; {{AE}} {{SC}} | {{CMG}}; {{AE}} {{Trusha}}{{SC}} {{Cherry}} | ||
==Overview== | ==Overview== | ||
Adenocarcinoma of the lung may be [[Classification|classified]] according to [[World Health Organization|WHO]] into many sub-types. Adenocarcinoma of the lung may be [[Classification|classified]] according to IASLC/ATS/ERS into pre-invasive [[Lesion|lesions]], [[Atypical adenomatous hyperplasia of the lung|atypical adenomatous hyperplasia]], adenocarcinoma in situ, minimally invasive adenocarcinoma, invasive adenocarcinoma, and variants of invasive adenocarcinoma. | |||
==Classification== | |||
* | * Adenocarcinomas are highly [[heterogeneous]] [[Tumor|tumors]]. | ||
* | * Several major [[Histology|histological]] sub-types are currently recognized by the [[World Health Organization|WHO]] and IASLC/ATS/ERS [[classification]] systems.<ref name="pmid21828029">{{Cite journal | pmid = 21828029| year = 2012| author1 = Van Schil| first1 = P. E.| title = Surgical implications of the new IASLC/ATS/ERS adenocarcinoma classification| journal = European Respiratory Journal| volume = 39| issue = 2| pages = 478-86| last2 = Asamura| first2 = H| last3 = Rusch| first3 = V. W.| last4 = Mitsudomi| first4 = T| last5 = Tsuboi| first5 = M| last6 = Brambilla| first6 = E| last7 = Travis| first7 = W. D.| doi = 10.1183/09031936.00027511}}</ref><ref>{{Cite journal | pmid = 21804158| year = 2011| author1 = Travis| first1 = W. D.| title = Paradigm shifts in lung cancer as defined in the new IASLC/ATS/ERS lung adenocarcinoma classification| journal = European Respiratory Journal| volume = 38| issue = 2| pages = 239-43| last2 = Brambilla| first2 = E| last3 = Van Schil| first3 = P| last4 = Scagliotti| first4 = G. V.| last5 = Huber| first5 = R. M.| last6 = Sculier| first6 = J. P.| last7 = Vansteenkiste| first7 = J| last8 = Nicholson| first8 = A. G.| doi = 10.1183/09031936.00026711}}</ref><ref>{{Cite journal | pmid = 18951650| year = 2009| author1 = Vazquez| first1 = M| title = Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: Histopathologic features and their prognostic implications| journal = Lung Cancer| volume = 64| issue = 2| pages = 148-54| last2 = Carter| first2 = D| last3 = Brambilla| first3 = E| last4 = Gazdar| first4 = A| last5 = Noguchi| first5 = M| last6 = Travis| first6 = W. D.| last7 = Huang| first7 = Y| last8 = Zhang| first8 = L| last9 = Yip| first9 = R| last10 = Yankelevitz| first10 = D. F.| last11 = Henschke| first11 = C. I.| author12 = International Early Lung Cancer Action Program Investigators| doi = 10.1016/j.lungcan.2008.08.009| pmc = 2849638}}</ref> | ||
*The IASLC/ATS/ERS lung adenocarcinoma [[Histology|histological]] [[classification]] system was proposed in 2011.<ref>{{cite journal|doi=10.3978/j.issn.2072-1439.2014.09.13}}</ref> | |||
*According to this new [[classification]], [[tumor]] size ≤ 3 cm with pure lepidic pattern, but without [[Lymph node metastases|lymphatic]], [[vascular]], and [[Pleura|pleural]] [[Invasive (medical)|invasion]] or tumor [[necrosis|necrosis,]] was defined as adenocarcinoma ''in situ'' (AIS). | |||
* | *If [[tumor]] size ≤ 3 cm with a lepidic predominant pattern and contained ≤ 5 mm [[stromal]] [[Invasive (medical)|invasion]], it was defined as minimally invasive adenocarcinoma (MIA). | ||
* | *If tumor had > 5 mm [[stromal]] [[Invasive (medical)|invasion]], it was defined as an invasive adenocarcinoma. | ||
* | |||
* | |||
* The [[World Health Organization|WHO]] [[Histology|histological]] [[classification]] of adenocarcinoma is following:<ref name="WHO">{{cite book | last = Travis | first = William | title = Pathology and genetics of tumours of the lung, pleura, thymus, and heart | publisher = IARC Press | location = Lyon | year = 2004 | isbn = 9283224183 }}</ref><ref name="urlwww.jto.org">{{cite web |url=https://www.jto.org/article/S1556-0864(15)33571-1/pdf |title=www.jto.org |format= |work= |accessdate=}}</ref> | |||
{| class="wikitable" | |||
|+ | |||
! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" ! | WHO Classification of Lung Tumors | |||
|- | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histological type | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Subtype | |||
''' | |- | ||
! colspan="2" style="background: #707070; color: #FFFFFF; text-align: center;" |Epithelial Tumors | |||
* | |- | ||
* Acinar | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Adenocarcinoma of the lung|'''Adenocarcinoma''']] | ||
* Papillary | | | ||
* | * Lepidic adenocarcinoma | ||
* Acinar adenocarcinoma | |||
* Papillary adenocarcinoma | |||
* Micropapillary adenocarcinoma | |||
* Solid adenocarcinoma | * Solid adenocarcinoma | ||
* Invasive mucinous adenocarcinoma | |||
** Mixed invasive mucinous | |||
** Nonmucinous adenocarcinoma | |||
* Colloid adenocarcinoma | |||
* Fetal adenocarcinoma | |||
* Enteric adenocarcinoma | |||
* Minimally invasive adenocarcinoma | |||
* Nonmucinous | |||
** Mucinous | |||
* Preinvasive lesions | |||
* | ** Atypical adenomatous hyperplasia | ||
** Adenocarcinoma in situ | |||
* | *** Nonmucinous | ||
*** Mucinous | |||
|} | |||
* Minimally | |||
* | |||
* | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 19:34, 17 September 2019
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Adenocarcinoma of the Lung Microchapters |
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Differentiating Adenocarcinoma of the Lung from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Adenocarcinoma of the lung classification On the Web |
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American Roentgen Ray Society Images of Adenocarcinoma of the lung classification |
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Risk calculators and risk factors for Adenocarcinoma of the lung classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Trusha Tank, M.D.[2]Shanshan Cen, M.D. [3] Sudarshana Datta, MD [4]
Overview
Adenocarcinoma of the lung may be classified according to WHO into many sub-types. Adenocarcinoma of the lung may be classified according to IASLC/ATS/ERS into pre-invasive lesions, atypical adenomatous hyperplasia, adenocarcinoma in situ, minimally invasive adenocarcinoma, invasive adenocarcinoma, and variants of invasive adenocarcinoma.
Classification
- Adenocarcinomas are highly heterogeneous tumors.
- Several major histological sub-types are currently recognized by the WHO and IASLC/ATS/ERS classification systems.[1][2][3]
- The IASLC/ATS/ERS lung adenocarcinoma histological classification system was proposed in 2011.[4]
- According to this new classification, tumor size ≤ 3 cm with pure lepidic pattern, but without lymphatic, vascular, and pleural invasion or tumor necrosis, was defined as adenocarcinoma in situ (AIS).
- If tumor size ≤ 3 cm with a lepidic predominant pattern and contained ≤ 5 mm stromal invasion, it was defined as minimally invasive adenocarcinoma (MIA).
- If tumor had > 5 mm stromal invasion, it was defined as an invasive adenocarcinoma.
- The WHO histological classification of adenocarcinoma is following:[5][6]
| WHO Classification of Lung Tumors | |
|---|---|
| Histological type | Subtype |
| Epithelial Tumors | |
| Adenocarcinoma |
|
References
- ↑ Van Schil, P. E.; Asamura, H; Rusch, V. W.; Mitsudomi, T; Tsuboi, M; Brambilla, E; Travis, W. D. (2012). "Surgical implications of the new IASLC/ATS/ERS adenocarcinoma classification". European Respiratory Journal. 39 (2): 478–86. doi:10.1183/09031936.00027511. PMID 21828029.
- ↑ Travis, W. D.; Brambilla, E; Van Schil, P; Scagliotti, G. V.; Huber, R. M.; Sculier, J. P.; Vansteenkiste, J; Nicholson, A. G. (2011). "Paradigm shifts in lung cancer as defined in the new IASLC/ATS/ERS lung adenocarcinoma classification". European Respiratory Journal. 38 (2): 239–43. doi:10.1183/09031936.00026711. PMID 21804158.
- ↑ Vazquez, M; Carter, D; Brambilla, E; Gazdar, A; Noguchi, M; Travis, W. D.; Huang, Y; Zhang, L; Yip, R; Yankelevitz, D. F.; Henschke, C. I.; International Early Lung Cancer Action Program Investigators (2009). "Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: Histopathologic features and their prognostic implications". Lung Cancer. 64 (2): 148–54. doi:10.1016/j.lungcan.2008.08.009. PMC 2849638. PMID 18951650.
- ↑ . doi:10.3978/j.issn.2072-1439.2014.09.13. Missing or empty
|title=(help) - ↑ Travis, William (2004). Pathology and genetics of tumours of the lung, pleura, thymus, and heart. Lyon: IARC Press. ISBN 9283224183.
- ↑ "www.jto.org".