Actinomycosis pathophysiology: Difference between revisions

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__NOTOC__
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{{Actinomycosis}}{{CMG}}
{{Actinomycosis}}
{{CMG}}; {{AE}}{{ADG}}
==Overview==
==Overview==
Actinomycosis is a chronic pyogenic bacterial infection caused by Actinomyces species. Infection most frequently follows dental work, trauma, surgery, or other medical conditions. When there is break in the mucosa, anywhere from the mouth to the rectum they reach tissues and cause damage. Incubation period of Actinomycosis varies from one to four weeks. But occasionally, it may be as long as several months. Actinomycosis elicits both humoral and cell-mediated immune responses
[[Actinomycosis]] is a chronic [[pyogenic]] [[bacterial]] [[infection]] caused by [[actinomyces]] species. Infection most frequently follows dental work, [[trauma]], [[surgery]], or other medical conditions. When there is break in the [[Mucosal|mucosa]], anywhere from the [[mouth]] to the [[rectum]] they reach tissues and cause damage. Incubation period of [[actinomycosis]] varies from one to four weeks. But occasionally, it may be as long as several months. [[Actinomycosis]] elicits both [[Humoral immunity|humoral]] and [[Cell-mediated immune response|cell-mediated immune responses]]


== Pathophysiology==
== Pathophysiology==
*Actinomycosis is caused by the bacteria [[Actinomyces]]. The pathophysiology of Actinomycosis can be described in the following steps. <ref name="pmid16116835">{{cite journal |vauthors=Volante M, Contucci AM, Fantoni M, Ricci R, Galli J |title=Cervicofacial actinomycosis: still a difficult differential diagnosis |journal=Acta Otorhinolaryngol Ital |volume=25 |issue=2 |pages=116–9 |year=2005 |pmid=16116835 |pmc=2639881 |doi= |url=}}</ref><ref name="pmid17561082">{{cite journal |vauthors=Sharkawy AA |title=Cervicofacial actinomycosis and mandibular osteomyelitis |journal=Infect. Dis. Clin. North Am. |volume=21 |issue=2 |pages=543–56, viii |year=2007 |pmid=17561082 |doi=10.1016/j.idc.2007.03.007 |url=}}</ref><ref name="Peipert2004">{{cite journal|last1=Peipert|first1=Jeffrey F.|title=Actinomyces: Normal Flora or Pathogen?|journal=Obstetrics & Gynecology|volume=104|issue=Supplement|year=2004|pages=1132–1133|issn=0029-7844|doi=10.1097/01.AOG.0000145267.59208.e7}}</ref><ref name="pmid28202870">{{cite journal |vauthors=Higashi Y, Nakamura S, Ashizawa N, Oshima K, Tanaka A, Miyazaki T, Izumikawa K, Yanagihara K, Yamamoto Y, Miyazaki Y, Mukae H, Kohno S |title=Pulmonary Actinomycosis Mimicking Pulmonary Aspergilloma and a Brief Review of the Literature |journal=Intern. Med. |volume=56 |issue=4 |pages=449–453 |year=2017 |pmid=28202870 |doi=10.2169/internalmedicine.56.7620 |url=}}</ref><ref name="pmid1612438">{{cite journal |vauthors=Schaal KP, Lee HJ |title=Actinomycete infections in humans--a review |journal=Gene |volume=115 |issue=1-2 |pages=201–11 |year=1992 |pmid=1612438 |doi= |url=}}</ref><ref name="Brown1973">{{cite journal|last1=Brown|first1=James R.|title=Human actinomycosisA study of 181 subjects|journal=Human Pathology|volume=4|issue=3|year=1973|pages=319–330|issn=00468177|doi=10.1016/S0046-8177(73)80097-8}}</ref>
*[[Actinomycosis]] is caused by the bacteria [[Actinomyces]]. The pathophysiology of actinomycosis can be described in the following steps. <ref name="pmid16116835">{{cite journal |vauthors=Volante M, Contucci AM, Fantoni M, Ricci R, Galli J |title=Cervicofacial actinomycosis: still a difficult differential diagnosis |journal=Acta Otorhinolaryngol Ital |volume=25 |issue=2 |pages=116–9 |year=2005 |pmid=16116835 |pmc=2639881 |doi= |url=}}</ref><ref name="pmid17561082">{{cite journal |vauthors=Sharkawy AA |title=Cervicofacial actinomycosis and mandibular osteomyelitis |journal=Infect. Dis. Clin. North Am. |volume=21 |issue=2 |pages=543–56, viii |year=2007 |pmid=17561082 |doi=10.1016/j.idc.2007.03.007 |url=}}</ref><ref name="Peipert2004">{{cite journal|last1=Peipert|first1=Jeffrey F.|title=Actinomyces: Normal Flora or Pathogen?|journal=Obstetrics & Gynecology|volume=104|issue=Supplement|year=2004|pages=1132–1133|issn=0029-7844|doi=10.1097/01.AOG.0000145267.59208.e7}}</ref><ref name="pmid28202870">{{cite journal |vauthors=Higashi Y, Nakamura S, Ashizawa N, Oshima K, Tanaka A, Miyazaki T, Izumikawa K, Yanagihara K, Yamamoto Y, Miyazaki Y, Mukae H, Kohno S |title=Pulmonary Actinomycosis Mimicking Pulmonary Aspergilloma and a Brief Review of the Literature |journal=Intern. Med. |volume=56 |issue=4 |pages=449–453 |year=2017 |pmid=28202870 |doi=10.2169/internalmedicine.56.7620 |url=}}</ref><ref name="pmid1612438">{{cite journal |vauthors=Schaal KP, Lee HJ |title=Actinomycete infections in humans--a review |journal=Gene |volume=115 |issue=1-2 |pages=201–11 |year=1992 |pmid=1612438 |doi= |url=}}</ref><ref name="Brown1973">{{cite journal|last1=Brown|first1=James R.|title=Human actinomycosisA study of 181 subjects|journal=Human Pathology|volume=4|issue=3|year=1973|pages=319–330|issn=00468177|doi=10.1016/S0046-8177(73)80097-8}}</ref>


===Transmission===
===Transmission===
*Actinomyces are part of natural flora of human body,resides in the oral cavity, lower gastrointestinal tract and urogenital tract.
*[[Actinomyces]] are part of the natural [[flora]] of human body, resides in the [[oral cavity]], lower [[gastrointestinal tract]] and [[Urogenital tract|urogenital tract.]]


*They are non virulent under normal conditions
*They are [[Virulence|nonvirulent]] under normal conditions
*When there is break in the mucosa, anywhere from the mouth to the rectum they reach tissues and cause damage.
*When there is a breach in normal [[mucosal]] architecture, anywhere from the [[mouth]] to the [[rectum]] they enter [[tissues]] and cause damage.
{| class="wikitable"
{| class="wikitable"
!Types
!Types
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!Source of infection
!Source of infection
|-
|-
!Cervicofacial actinomycosis
![[Cervicofacial actinomycosis]]
|
|
* Neck
* [[Neck]]


* Jaw
* [[Jaw]]


* Mouth
* [[Mouth]]
|
|
* Dental problems like tooth decay
* Dental problems like [[tooth decay]]
|-
|-
!Thoracic  
![[Thoracic actinomycosis|Thoracic]]


actinomycosis
[[Thoracic actinomycosis|actinomycosis]]
|
|
* Lungs  
* [[Lungs]]
* Pleura  
* [[Pleura]]
* Chest wall  
* [[Chest wall]]
* Mediastinum  
* [[Mediastinum]]
|
|
* Inhalation of droplets of contaminated fluid
* [[Inhalation]] of [[droplets]] of contaminated [[fluid]]
* Aspiration of oropharyngeal secretions or gastric contents
* [[Aspiration]] of [[oropharyngeal]] secretions or [[gastric]] contents
* Direct extension of cervicofacial infection into the mediastinum
* Direct extension of cervicofacial infection into the [[mediastinum]]
* Transdiaphragmatic or retroperitoneal spread from the abdomen
* Transdiaphragmatic or [[retroperitoneal]] spread from the [[abdomen]]
* Hematogenous spread
* Hematogenous spread
|-
|-
!Abdominal actinomycosis
!Abdominal actinomycosis
|Abdomen
|[[Abdomen]]
|
|
* Secondary to abdominal infections like appendicitis
* Secondary to [[abdominal]] [[infections]] like [[appendicitis]]


* Accidental swallowing of a foreign body such as chicken bone containing the actinomycetes bacteria
* Accidental swallowing of a foreign body such as chicken bone containing the [[Actinomycetes|actinomycetes bacteria]]
* Penetrating trauma
* [[Penetrating trauma]]
* Perforation of the gut (e.g., the colon or appendix)  
* [[Perforation of inflamed diverticulum|Perforation of the gut]] (e.g., the [[colon]] or [[appendix]])  
* Surgical manipulation of GI tract  
* Surgical manipulation of [[GI tract]]
|-
|-
!Pelvic  
!Pelvic  
actinomycosis
actinomycosis
|Pelvis
|[[Pelvis]]
|
|
* Occurs most commonly in woman as the bacteria passes from the female genitals into the pelvis
* Occurs most commonly in woman as the [[bacteria]] enters into the [[pelvis]]
* Long-term use of IUD type of contraceptive  
* Long-term use of [[IUD]] type of contraceptive  
|-
|-
!Central nervous system
![[Central nervous system actinomycosis|Central nervous system]]
actinomycosis
[[Central nervous system actinomycosis|actinomycosis]]
|CNS
|[[CNS]]
|
|
* Secondary to hematogenous spread from primary infection in the lung, abdomen, or pelvis
* Secondary to hematogenous spread from primary [[infection]] in the [[lung]], [[Abdomen|abdomen,]] or [[pelvis]]
* Direct extension from paranasal sinuses, ears, and cervicofacial regions<ref name="pmid3317731">{{cite journal| author=Smego RA| title=Actinomycosis of the central nervous system. | journal=Rev Infect Dis | year= 1987 | volume= 9 | issue= 5 | pages= 855-65 | pmid=3317731 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3317731  }} </ref>  
* Direct extension from [[paranasal sinuses]], [[ears]], and cervicofacial regions<ref name="pmid3317731">{{cite journal| author=Smego RA| title=Actinomycosis of the central nervous system. | journal=Rev Infect Dis | year= 1987 | volume= 9 | issue= 5 | pages= 855-65 | pmid=3317731 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3317731  }} </ref>  
|}
|}


===Incubation ===
===Incubation ===
[[Incubation period]] of Actinomycosis varies from one to four weeks. But occasionally, it may be as long as several months. 
[[Incubation period]] of [[actinomycosis]] varies from one to four weeks.
=== '''Dissemination''' ===
=== '''Dissemination''' ===
Following transmission, lesions spread by direct extension.
Following transmission, lesions spread by direct extension.
===Seeding===
===Seeding===
*Once the endogenous bacteria are introduced into the tissues, they multiply due to low oxygen tension.
*Once the [[Endogenous|endogenous bacteria]] are introduced into the [[tissues]], they multiply due to low [[oxygen]] tension.
*It triggers an inflammatory reaction which results in formation of hard yellow hard granules(sulfur granules).
*It leads to the formation of hard yellow hard granules ([[sulfur]] [[granules]]).
*These are solidified bacterial filaments with surrounding tissue exudates.
*These granules represent solidified bacterial filaments with surrounding tissue [[Exudate|exudates.]]
*Abscesses with fibrous walls and pus along with sulfur granules develop.
*These triggers an [[Inflammatory responses|inflammatory reaction]].
*It finally drain out through sinuses.
*[[Inflammation|Inflammatory]] mediators along with various [[Toxins|bacterial toxins]] and [[Proteolytic enzyme|proteolytic]] enzymes from the [[neutrophils]] are released leading to [[abscess]] formation.
*A fibrous wall develops around the [[abscess]].
*Extension of the abscess to [[skin]] leads to the formation of sinus tracts and [[Pustulate|pus]] drains out through these sinuses.
===Immune response===
===Immune response===
Actinomycosis elicits both [[Humoral immunity|humoral]] and [[Cell-mediated immunity|cell-mediated]] [[immune]] responses
[[Actinomycosis]] elicits both [[Humoral immunity|humoral]] and [[Cell-mediated immunity|cell-mediated]] [[immune]] responses


==Genetics==
==Genetics==
There is no known genetic association to Actinomycosis
There is no known genetic association to [[actinomycosis]]
==Gross Pathology==
==Gross Pathology==
On gross pathology the following features can be noticed:
On gross pathology, the following features can be noticed:
*Single or multiple abscesses  
*Single or multiple [[abscesses]]
*Indurated masses with hard fibrous walls and soft central loculations containing white or yellow pus.  
*[[Induration|Indurated]] masses with hard fibrous walls and soft central loculations containing white or yellow pus.  
*Granules are seen grossly.  
*[[Granules]] are seen grossly.  
*Sinus tracts extended from abscesses to the skin surface or into organs; vertebral bone, and retroperitoneal tissue.
*[[Sinus]] tracts extended from [[abscesses]] to the [[skin]] surface or into organs; [[Vertebra|vertebral bone]], and [[retroperitoneal]] [[tissue]].
*Pleural, pericardial, or serosal thickening with infection of the lung, heart, and wall of the bowel.
*[[Pleural]], [[pericardial]], or [[Serosa|serosal]] thickening if the [[infection]] involves [[lung]], [[heart]], and [[Bowel|wall of the bowel.]]


==Microscopic pathology==
==Microscopic pathology==
*Outer zone of granulation around central purulent abscess.
Microscopic findings include
*Positive for sulphur granules in the center of abscess.
*[[Liquefaction]] type of [[necrosis]] in the center of [[abscess]] with a surrounding outer layer of [[granulation tissue]] along with [[lymphocytes]] and [[neutrophils]].
*Focal liquefication type of necrosis is seen.
*[[Gram-positive]] [[organism]] with branching [[filaments]] like structures appear as colonies.  
*Lymphocytes and neutrophils forms a layer around the abscess.
[[Image: Actinomycosis1.jpg|center|alt=This is a low-power photomicrograph of the retroperitoneal abscess. At this magnification, multiple dark-staining foci can be appreciated. These foci are Actinomyces colonies (arrows). These colonies are known as "sulfur granules" because in gross specimens they are visible to the naked eye as yellow grains, thus resembling grains of sulfur.|This is a low-power photomicrograph of the retroperitoneal abscess. At this magnification, multiple dark-staining foci can be appreciated. These foci are Actinomyces colonies (arrows). These colonies are known as "sulfur granules" because in gross specimens they are visible to the naked eye as yellow grains, thus resembling grains of sulfur.|frame|400px|]]\
*Gram positive organism with branching filaments forming segment-like structures.  
[[Image: Actinomycosis1.jpg|center|alt=This is a low-power photomicrograph of the retroperitoneal abscess. At this magnification, multiple dark-staining foci can be appreciated. These foci are Actinomyces colonies (arrows). These colonies are known as "sulfur granules" because in gross specimens they are visible to the naked eye as yellow grains, thus resembling grains of sulfur.|This is a low-power photomicrograph of the retroperitoneal abscess. At this magnification, multiple dark-staining foci can be appreciated. These foci are Actinomyces colonies (arrows). These colonies are known as "sulfur granules" because in gross specimens they are visible to the naked eye as yellow grains, thus resembling grains of sulfur.|frame]]\




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[[Category:Bacterial diseases]]
[[Category:Bacterial diseases]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Infectious disease]]
 
[[Category:Overview complete]]
[[Category:Overview complete]]
[[Category:Dermatology]]
[[Category:Dermatology]]

Latest revision as of 16:18, 18 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

Actinomycosis is a chronic pyogenic bacterial infection caused by actinomyces species. Infection most frequently follows dental work, trauma, surgery, or other medical conditions. When there is break in the mucosa, anywhere from the mouth to the rectum they reach tissues and cause damage. Incubation period of actinomycosis varies from one to four weeks. But occasionally, it may be as long as several months. Actinomycosis elicits both humoral and cell-mediated immune responses

Pathophysiology

Transmission

Types Site of Infection Source of infection
Cervicofacial actinomycosis
Thoracic

actinomycosis

Abdominal actinomycosis Abdomen
Pelvic

actinomycosis

Pelvis
  • Occurs most commonly in woman as the bacteria enters into the pelvis
  • Long-term use of IUD type of contraceptive
Central nervous system

actinomycosis

CNS

Incubation

Incubation period of actinomycosis varies from one to four weeks.

Dissemination

Following transmission, lesions spread by direct extension.

Seeding

Immune response

Actinomycosis elicits both humoral and cell-mediated immune responses

Genetics

There is no known genetic association to actinomycosis

Gross Pathology

On gross pathology, the following features can be noticed:

Microscopic pathology

Microscopic findings include

This is a low-power photomicrograph of the retroperitoneal abscess. At this magnification, multiple dark-staining foci can be appreciated. These foci are Actinomyces colonies (arrows). These colonies are known as "sulfur granules" because in gross specimens they are visible to the naked eye as yellow grains, thus resembling grains of sulfur.

\


{{#ev:youtube|pvasI_yy3R4}}

References

  1. Volante M, Contucci AM, Fantoni M, Ricci R, Galli J (2005). "Cervicofacial actinomycosis: still a difficult differential diagnosis". Acta Otorhinolaryngol Ital. 25 (2): 116–9. PMC 2639881. PMID 16116835.
  2. Sharkawy AA (2007). "Cervicofacial actinomycosis and mandibular osteomyelitis". Infect. Dis. Clin. North Am. 21 (2): 543–56, viii. doi:10.1016/j.idc.2007.03.007. PMID 17561082.
  3. Peipert, Jeffrey F. (2004). "Actinomyces: Normal Flora or Pathogen?". Obstetrics & Gynecology. 104 (Supplement): 1132–1133. doi:10.1097/01.AOG.0000145267.59208.e7. ISSN 0029-7844.
  4. Higashi Y, Nakamura S, Ashizawa N, Oshima K, Tanaka A, Miyazaki T, Izumikawa K, Yanagihara K, Yamamoto Y, Miyazaki Y, Mukae H, Kohno S (2017). "Pulmonary Actinomycosis Mimicking Pulmonary Aspergilloma and a Brief Review of the Literature". Intern. Med. 56 (4): 449–453. doi:10.2169/internalmedicine.56.7620. PMID 28202870.
  5. Schaal KP, Lee HJ (1992). "Actinomycete infections in humans--a review". Gene. 115 (1–2): 201–11. PMID 1612438.
  6. Brown, James R. (1973). "Human actinomycosisA study of 181 subjects". Human Pathology. 4 (3): 319–330. doi:10.1016/S0046-8177(73)80097-8. ISSN 0046-8177.
  7. Smego RA (1987). "Actinomycosis of the central nervous system". Rev Infect Dis. 9 (5): 855–65. PMID 3317731.

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