Actinomycosis natural history
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Once in the tissue, actinomyces multiply and forms an abscess, producing a hard, red to reddish-purple lump, most commonly on the jaw. Eventually, the abscess ruptures through the skin surface producing a draining sinus tract. If left untreated, patients with actinomycosis may progress to develop multiple abscesses which can heal and reappear. The prognosis is excellent with prompt and effective antimicrobial treatment. Complications that can develop as a result of actinomycosis are osteomyelitis, endocarditis, pericarditis and meningitis.
- Once in the tissue, actinomyces multiply and forms an abscess, producing a hard, red to reddish-purple lump, often on the jaw.
- Eventually, the abscess ruptures through the skin surface to produce a draining sinus tract and are completely treatable.
- If left untreated, patients with actinomycosis may progress to develop focal organ involvement with mass-like features and multiple abscesses which can heal and reform.
- The prognosis is excellent with prompt and effective antimicrobial treatment in patients with uncomplicated actinomycosis that does not affect the CNS.
- The factors that define the outcomes of the disease include:
- Site of infection
- The time to diagnose
- The time to the start of appropriate treatment
- Mortality range from 0% to 28% highest being in CNS.
- Extension of disease can result in osteomyelitis of the mandible, ribs, or vertebrae.
- Brain abscess
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