Actinomycosis natural history: Difference between revisions
Jump to navigation
Jump to search
Aditya Ganti (talk | contribs) |
Aditya Ganti (talk | contribs) |
||
| Line 5: | Line 5: | ||
==Natural History== | ==Natural History== | ||
Once in the tissue, | *Once in the tissue, actinomyces multiply and forms an [[abscess]], producing a hard, red to reddish-purple lump, often on the jaw. | ||
*Eventually, the abscess breaks through the skin surface to produce a draining sinus tract. | |||
*With treatment, it is completely treatable. | |||
*If left untreated, patients with actinomycosis may progress to develop focal organ involvement with mass-like features and development of sinus tracts (which can heal and re-form) leading to multiple abscess.<ref name="pmid16116835">{{cite journal |vauthors=Volante M, Contucci AM, Fantoni M, Ricci R, Galli J |title=Cervicofacial actinomycosis: still a difficult differential diagnosis |journal=Acta Otorhinolaryngol Ital |volume=25 |issue=2 |pages=116–9 |year=2005 |pmid=16116835 |pmc=2639881 |doi= |url=}}</ref><ref name="pmid17561082">{{cite journal |vauthors=Sharkawy AA |title=Cervicofacial actinomycosis and mandibular osteomyelitis |journal=Infect. Dis. Clin. North Am. |volume=21 |issue=2 |pages=543–56, viii |year=2007 |pmid=17561082 |doi=10.1016/j.idc.2007.03.007 |url=}}</ref><ref name="Peipert2004">{{cite journal|last1=Peipert|first1=Jeffrey F.|title=Actinomyces: Normal Flora or Pathogen?|journal=Obstetrics & Gynecology|volume=104|issue=Supplement|year=2004|pages=1132–1133|issn=0029-7844|doi=10.1097/01.AOG.0000145267.59208.e7}}</ref><ref name="pmid28202870">{{cite journal |vauthors=Higashi Y, Nakamura S, Ashizawa N, Oshima K, Tanaka A, Miyazaki T, Izumikawa K, Yanagihara K, Yamamoto Y, Miyazaki Y, Mukae H, Kohno S |title=Pulmonary Actinomycosis Mimicking Pulmonary Aspergilloma and a Brief Review of the Literature |journal=Intern. Med. |volume=56 |issue=4 |pages=449–453 |year=2017 |pmid=28202870 |doi=10.2169/internalmedicine.56.7620 |url=}}</ref><ref name="pmid1612438">{{cite journal |vauthors=Schaal KP, Lee HJ |title=Actinomycete infections in humans--a review |journal=Gene |volume=115 |issue=1-2 |pages=201–11 |year=1992 |pmid=1612438 |doi= |url=}}</ref><ref name="Brown1973">{{cite journal|last1=Brown|first1=James R.|title=Human actinomycosisA study of 181 subjects|journal=Human Pathology|volume=4|issue=3|year=1973|pages=319–330|issn=00468177|doi=10.1016/S0046-8177(73)80097-8}}</ref> | |||
==Prognosis== | ==Prognosis== | ||
Revision as of 18:05, 30 March 2017
|
Actinomycosis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Actinomycosis natural history On the Web |
|
American Roentgen Ray Society Images of Actinomycosis natural history |
|
Risk calculators and risk factors for Actinomycosis natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Once in the tissue, Actinomyces multiply and forms an abscess, producing a hard, red to reddish-purple lump, often on the jaw, from which comes the condition's common name, "lumpy jaw." Eventually, the abscess breaks through the skin surface to produce a draining sinus tract. With treatment, it is completely treatable.
Natural History
- Once in the tissue, actinomyces multiply and forms an abscess, producing a hard, red to reddish-purple lump, often on the jaw.
- Eventually, the abscess breaks through the skin surface to produce a draining sinus tract.
- With treatment, it is completely treatable.
- If left untreated, patients with actinomycosis may progress to develop focal organ involvement with mass-like features and development of sinus tracts (which can heal and re-form) leading to multiple abscess.[1][2][3][4][5][6]
Prognosis
- The prognosis is generally excellent with prompt and effective antimicrobial treatment in patients with uncomplicated actinomycosis that does not affect the CNS.
- The factors that define the outcomes of the diesease include
- Site of infection: the highest mortality is seen if the disease involves central nervous system.
- The time to diagnosis: delayed presentation results in poorer outcomes
- The time to the start of appropriate treatment.
- Mortality range from 0% to 28%.( hightest being in CNS)
Complications
Complications that can develop as a result of actinomycosis are [7]
- Extension of disease can result in osteomyelitis of the mandible, ribs, or vertebrae.
- Endocarditis
- Pericarditis
- CNS disease, including brain abscess; chronic meningitis
References
- ↑ Volante M, Contucci AM, Fantoni M, Ricci R, Galli J (2005). "Cervicofacial actinomycosis: still a difficult differential diagnosis". Acta Otorhinolaryngol Ital. 25 (2): 116–9. PMC 2639881. PMID 16116835.
- ↑ Sharkawy AA (2007). "Cervicofacial actinomycosis and mandibular osteomyelitis". Infect. Dis. Clin. North Am. 21 (2): 543–56, viii. doi:10.1016/j.idc.2007.03.007. PMID 17561082.
- ↑ Peipert, Jeffrey F. (2004). "Actinomyces: Normal Flora or Pathogen?". Obstetrics & Gynecology. 104 (Supplement): 1132–1133. doi:10.1097/01.AOG.0000145267.59208.e7. ISSN 0029-7844.
- ↑ Higashi Y, Nakamura S, Ashizawa N, Oshima K, Tanaka A, Miyazaki T, Izumikawa K, Yanagihara K, Yamamoto Y, Miyazaki Y, Mukae H, Kohno S (2017). "Pulmonary Actinomycosis Mimicking Pulmonary Aspergilloma and a Brief Review of the Literature". Intern. Med. 56 (4): 449–453. doi:10.2169/internalmedicine.56.7620. PMID 28202870.
- ↑ Schaal KP, Lee HJ (1992). "Actinomycete infections in humans--a review". Gene. 115 (1–2): 201–11. PMID 1612438.
- ↑ Brown, James R. (1973). "Human actinomycosisA study of 181 subjects". Human Pathology. 4 (3): 319–330. doi:10.1016/S0046-8177(73)80097-8. ISSN 0046-8177.
- ↑ Agrawal P, Vaiphei K (2014). "Renal actinomycosis". BMJ Case Rep. 2014. doi:10.1136/bcr-2014-205892. PMC 4244330. PMID 25406215.
de:Aktinomykose gl:Actinomicose hr:Aktinomikoza nl:Actinomycose sr:Актиномикоза fi:Aktinomykoosi uk:Актиномікоз