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| | __NOTOC__ |
| | {| class="infobox" style="float:right;" |
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| | | [[File:Siren.gif|30px|link=Abdominal aortic aneurysm resident survival guide]]|| <br> || <br> |
| | | [[Abdominal aortic aneurysm resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']] |
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| {{Template:Abdominal aortic aneurysm}} | | {{Template:Abdominal aortic aneurysm}} |
| | '''For patient information click [[Abdominal aortic aneurysm (patient information)|here]]''' |
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| {{SI}} | | {{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}} {{RG}} |
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| {{CMG}} | | {{SK}} Abdominal aneurysm, aortic; aortic aneurysm, abdominal; AAA; triple A |
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| '''Associate Editor-In-Chief:''' {{CZ}}
| | ==[[Abdominal aortic aneurysm overview|Overview]]== |
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| | ==[[Abdominal aortic aneurysm historical perspective|Historical Perspective]]== |
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| | ==[[Abdominal aortic aneurysm classification|Classification]]== |
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| {{Editor Help}}
| | ==[[Abdominal aortic aneurysm pathophysiology|Pathophysiology]]== |
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| ==[[Abdominal aortic aneurysm overview|Overview]]== | | ==[[Abdominal aortic aneurysm causes|Causes]]== |
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| ==[[Abdominal aortic aneurysm pathophysiology|Pathophysiology & Etiology]]== | | ==[[Abdominal aortic aneurysm differential diagnosis|Differentiating Abdominal Aortic Aneurysm from other Diseases]]== |
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| ==[[Abdominal aortic aneurysm epidemiology and demographics|Epidemiology and Demographics]]== | | ==[[Abdominal aortic aneurysm epidemiology and demographics|Epidemiology and Demographics]]== |
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| ==[[Abdominal aortic aneurysm screening|Screening]]== | | ==[[Abdominal aortic aneurysm screening|Screening]]== |
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| | ==[[Abdominal aortic aneurysm natural history|Natural History, Complications and Prognosis]]== |
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| == Diagnosis == | | == Diagnosis == |
| [[Abdominal aortic aneurysm history and symptoms|History & symptoms]] | [[Abdominal aortic aneurysm physical examination|Physical examination]] | [[Abdominal aortic aneurysm laboratory tests|Lab tests]] | [[Abdominal aortic aneurysm electrocardiogram|Electrocardiogram]] | [[Abdominal aortic aneurysm chest x ray|Chest X Ray]] | [[Abdominal aortic aneurysm MRI & MRA|MRI & MRA]] | [[Abdominal aortic aneurysm CT|CT]] | [[abdominal aortic aneurysm echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Abdominal aortic aneurysm Aortography|Aortography]] | [[Abdominal aortic aneurysm other diagnostic findings|Other diagnostic findings]] | [[Abdominal aortic aneurysm pathological findings|Pathological findings]] | | [[Abdominal aortic aneurysm history and symptoms|History and Symptoms]] | [[Abdominal aortic aneurysm physical examination|Physical Examination]] | [[Abdominal aortic aneurysm abdominal x ray|Abdominal X Ray]] | [[abdominal aortic aneurysm ultrasound|Ultrasound]] | [[Abdominal aortic aneurysm CT|CT]] | [[Abdominal aortic aneurysm MRI|MRI]] | [[Abdominal aortic aneurysm other imaging findings|Other Imaging Findings]] |
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| === Magnetic Resonance Angiography (MRA) ===
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| * Does not require nephrotoxic contrast
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| * Less accurate than thin-slice CT
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| * Costly, and is not as readily available as contrast CT and ultrasonography
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| === Echocardiography or Ultrasound ===
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| * Ultrasonography has a sensitivity close to 100%
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| *:* Well accepted by patients
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| *:* The preferred method for detecting and following the progression of AAAs
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| *:* Able to show the dimensions of the abdominal aorta and other relevant findings:
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| *:*:* Mural thrombus
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| *:*:* Iliac artery aneurysms
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| *:* Patients should fast before examination to optimize image quality.
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| === Contrast Aortography ===
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| * Performed before surgery in patients suspected of having the following:
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| *:* Suprapenal or juxtarenal aneurysms
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| *:* Renovascular hypertension
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| *:* Ischemic nephropathy
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| *:* Mesenteric ischemia
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| *:* Associated iliofemoral arterial occlusive disease
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| * Should not be used to assess the size of an AAA because the common presence of mural thrombus often leads to diameter underestimation
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| == Treatment == | | == Treatment == |
| | [[Abdominal aortic aneurysm medical therapy|Medical Therapy]] | [[Abdominal aortic aneurysm surgery|Surgery]] | [[Abdominal aortic aneurysm prevention|Prevention]] |
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| === Acute Pharmacotherapies === | | ==Case Studies== |
| *Antimetalloproteases such as [[doxycycline]] and [[roxithromycin]] may halt aneurysm expansion
| | [[Abdominal aortic aneurysm case study one|Case #1]] |
| *Similarly, [[NSAID|non-steriod anti inflammatory drugs]] have shown to be beneficial in small studies
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| *[[Beta blocker]]s have numerous benefits in patients with cardiovascular disease
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| *:*Reduce aortic complications in patients with [[Marfan syndrome]]
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| *:*Slow progression of AAAs in hypertensive patients
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| *:*In the absence of other indications for [[beta blocker]]s, the evidence is insufficient to recommend using them routinely for the sole purpose of slowing atherosclerotic aneurysm growth
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| === Surgery and Device Based Therapy ===
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| ==== Indications for Surgery ====
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| The treatment options for asymptomatic AAA are immediate repair, surveillance with a view to eventual repair, and [[wiktionary:conservative treatment|conservative]].
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| There are currently two modes of repair available for an AAA: open aneurysm repair (OR), and endovascular aneurysm repair ([[EVAR]]).
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| * ''Conservative treatment'' is indicated in patients where repair carries a high risk of mortality and also in patients where repair is unlikely to improve life expectancy. The two mainstays of the conservative treatment are [[tobacco smoking|smoking]] cessation and [[blood pressure]] control.
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| * ''Surveillance'' is indicated in small aneurysms, where the risk of repair exceeds the risk of rupture. As an AAA grows in diameter the risk of rupture increases. Although some controversy exists around the world, most vascular surgeons would not consider repair until the aneurysm reached a diameter of 5cm. The threshold for repair varies slightly from individual to individual, depending on the balance of risks and benefits when considering repair versus ongoing surveillance. The size of an individual's native aorta may influence this, along with the presence of comorbitities that increase operative risk or decrease life expectancy.
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| * ''Open repair'' (operation) is indicated in young patients as an elective procedure, or in growing or large, symptomatic or ruptured aneurysms. Open repair has been the mainstay of intervention from the 1950's until recently.
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| * ''Endovascular repair'' first became practical in the 1990's and although it is now an established alternative to open repair, its role is yet to be clearly defined. It is generally indicated in older, high-risk patients or patients unfit for open repair. However, endovascular repair is feasible for only a proportion of AAA's, depending on the morphology of the aneurysm. The main advantage over open repair is that the peri-operative period has less impact on the patient (less time in intensive care, less time in hospital overall, earlier return to normal activity). Disadvantages of endovascular repair include a requirement for more frequent ongoing hospital reviews, and a higher chance of further procedures being required. According to the latest studies, the EVAR procedure doesn't offer any overall survival benefit.<ref name="pmid16782510">Rutherford RB. Randomized EVAR Trials and Advent of Level I Evidence: A Paradigm Shift in Management of Large Abdominal Aortic Aneurysms? ''Semin Vasc Surg'' 2006; '''19''':69-74. PMID 16782510</ref> Regarding unruptured aneurysms, EVAR is associated with lower operative mortality than open repair but unknown long-term mortality<ref name="pmid17502634">{{cite journal |author=Lederle FA, Kane RL, MacDonald R, Wilt TJ |title=Systematic review: repair of unruptured abdominal aortic aneurysm |journal=Ann. Intern. Med. |volume=146 |issue=10 |pages=735-41 |year=2007 |pmid=17502634 |doi=}}</ref>
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| ==== Pre-Operative Assessment ====
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| * The ADAM trial suggested that the "biological age," as reflected by the condition of the vital organs such as the lungs, kidneys, heart was more important than the chronological age as a determinant of operative outcome. <cite>ADAMref4</cite>
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| * Patients with poor renal and pulmonary function have worse operative outcomes
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| *:* Chronic obstructive pulmonary disease
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| *:* Elevated creatinine concentrations
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| *:* Electrocardiographic evidence of ischemia
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| * Aortic factors implicated in postoperative morbidity and mortality include:
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| *:* Extensive atheromatous disease
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| *:* Mural calcification
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| *:* Thrombosis
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| *:* Juxtarenal extension of aneurysm
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| *:* Inflammatory aortic aneurysms
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| *:* The increased risk resulted from:
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| *:*:* Longer suprapenal clamping time
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| *:*:* Need for complex dissection
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| *:*:* Increased hemodynamic stresses
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| ==Pathological Findings==
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| [http://www.peir.net Images shown below are courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 1.jpg|Dissecting Aneurysm: Gross very good example dissected channel has been opened
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| Image:Aortic aneurysm 2.jpg|Dissecting Aneurysm: Gross external view good appearance from adventitia
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| Image:Aortic aneurysm 3.jpg|Dissecting Aneurysm: Gross opened false channel
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 4.jpg|Dissecting Aneurysm: Gross good example dissection beginning at third portion aortic arch
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| Image:Aortic aneurysm 5.jpg|Dissecting Aneurysm: Gross cross sections showing thrombus in false lumen true lumen has been opened longitudinally
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| Image:Aortic aneurysm 6.jpg|Dissecting Aneurysm: Gross shows origin just above aortic valve false channel shown in descending thoracic aorta (very good example)
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 7.jpg|Atherosclerotic Aneurysm: Gross, a good example of typical abdominal aorta aneurysm with mural thrombus
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| Image:Aortic aneurysm 8.jpg|Dissecting Aneurysm: Gross, a very good example of dissection beginning just above aortic ring
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| Image:Aortic aneurysm 9.jpg|Atherosclerotic Aneurysm: Gross, (rather) good example of abdominal aortic aneurysm
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 10.jpg|Dissecting Aneurysm: Gross, an excellent example, starting just above the aortic valve with reflection of aorta to show the dissection tract and some thrombus
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| Image:Aortic aneurysm 11.jpg|Dissecting Aneurysm: Gross shows dilated aorta with extensive atherosclerosis dissection is seen, a small abdominal aorta atherosclerotic aneurysm is present good for association of dilation with dissection
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| Image:Aortic aneurysm 12.jpg|Dissecting Aneurysm: Gross arrow points to start of dissection in first portion aortic arch good but not the best example shows dilation
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 13.jpg|Dissecting Aneurysm: Gross, very good to show start of dissection above aortic valve and blood in false channel
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| Image:Aortic aneurysm 14.jpg|Dissecting Aneurysm: Gross, heart with root of aorta to show hemorrhage into pericardium (a very good example)
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| Image:Aortic aneurysm 15.jpg|Dissecting Aneurysm: Gross, of heart and aorta with dissection and large false channel (a good example)
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 16.jpg|Dissecting Aneurysm: Gross cross section of aorta with two channels (a good example)
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| Image:Aortic aneurysm 17.jpg|Atherosclerotic Aneurysm: Gross, a nice view of cross section of abdominal aorta aneurysm
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| Image:Aortic aneurysm 18.jpg|Dissecting Aneurysm: Gross good example of typical angular tear above aortic valve
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 19.jpg|Dissecting Aneurysm: Gross good example angular tear above aortic valve
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| Image:Aortic aneurysm 20.jpg|Atherosclerotic Aneurysm: Gross, external natural color very good example of an atherosclerotic thoracic aorta aneurysm with focal rupture
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| Image:Aortic aneurysm 21.jpg|Atherosclerotic Aneurysm: Gross, excellent color, opened thoracic segment of aorta with two saccular atherosclerotic ruptured aneurysms
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 22.jpg|Atherosclerotic Aneurysm: Gross, an excellent example, natural color, external view of typical thoracic aortic aneurysms
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| Image:Aortic aneurysm 23.jpg|Atherosclerotic Aneurysm: Gross unopened lesion natural color
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| Image:Aortic aneurysm 24.jpg|Dissecting Aneurysm: Gross dissection first portion of arch fixed specimen (a good example)
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 25.jpg|Dissecting Aneurysm: Gross, rather well shown dissection in first portion of the aortic arch
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| Image:Aortic aneurysm 26.jpg|Dissecting Aneurysm: Gross, rather well shown dissection in first portion of the aortic arch
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| Image:Aortic aneurysm 27.jpg|Dissecting Aneurysm: Gross, an excellent example of type I lesion
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 28.jpg|Dissecting Aneurysm: Gross, external view, an excellent example
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| Image:Aortic aneurysm 29.jpg|Dissecting Aneurysm: Gross, Type I shows false channel
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| Image:Aortic aneurysm 30.jpg|Dissecting Aneurysm: Gross, opened to show false channel (good example)
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| </gallery>
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| </div>
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| | ==Related Chapters== |
| | *[[Aorta]] |
| | *[[Aortic dissection]] |
| | *[[Thoracic aortic aneurysm]] |
| | *[[Syphilitic aortitis]] |
| | *[[Acute aortic syndrome]] |
| | *[[Penetrating atherosclerotic aortic ulcer]] |
| | *[[Aortic intramural hematoma]] |
| | *[[Aortic rupture]] <br /> |
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| | {{WikiDoc Help Menu}} |
| | {{WikiDoc Sources}} |
| | [[CME Category::Cardiology]] |
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| <div align="left">
| | [[Category:Disease]] |
| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 31.jpg|Atherosclerotic Aneurysm: Gross, very good example of ruptured thoracic segment
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| Image:Aortic aneurysm 32.jpg|Dissecting Aneurysm: Gross, coagulum of blood in false channel
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| Image:Aortic aneurysm 33.jpg|Dissecting Aneurysm: Gross, aortic valve area dissection (well shown, typical lesion)
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 34.jpg|Abdominal Aneurysm Ruptured: Gross (good example) opened kidneys in marked place, atherosclerosis in lower thoracic aorta
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| Image:Aortic aneurysm 35.jpg|Abdominal Aneurysm: Gross, (very good example) opened lesion with mural thrombus
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| Image:Aortic aneurysm 36.jpg|Dissecting Aneurysm: Gross, large tear in first portion of aortic arch, annuloaortic ectasis
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| </gallery>
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| </div>
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 37.jpg|Dissecting Aneurysm: Gross, external view of heart and first portion of aortic arch, annuloaortic ectasia, hemorrhage beneath adventitia is evidence of dissection
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| Image:Aortic aneurysm 38.jpg|Atherosclerotic Aneurysm Infected: Gross, infected abdominal aneurysm at superior suture line with rupture into duodenum
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| Image:Aortic aneurysm 39.jpg|Atherosclerotic Aneurysm: Gross, cross sections of repaired aneurysm showing Dacron graft and old mural thrombus. A nice example of fibrin layer in graft
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 40.jpg|Ruptured Syphilitic Aneurysm
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| Image:Aortic aneurysm 41.jpg|Dissecting Aneurysm in a patient with [[Marfan's syndrome]]
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| Image:Aortic aneurysm 42.jpg|Traumatic Aneurysm
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 43.jpg|Kidney: Arteriosclerosis: Gross aorta with well shown renal artery containing large plaque and kidney with multiple cortical scars and atrophy also abdominal aorta aneurysm with mural thrombus (excellent example for renovascular hypertension)
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| Image:Aortic aneurysm 44.jpg|Dissecting Aneurysm: Gross, fixed tissue, descending thoracic segment dissection opened to show the false channel. The true surface is also visible
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| Image:Aortic aneurysm 45.jpg|Aneurysm: Gross, ruptured thoracic aorta aneurysm, in situ lower thoracic portion (probably due to atherosclerosis)
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 46.jpg|Abdominal Aneurysm Graft Repair: Gross, natural color, close-up view, an excellent example of Dacron graft that has been in place for years with pseudointima and atherosclerosis
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| Image:Aortic aneurysm 47.jpg|Dacron Graft: Gross, close-up Dacron graft to repair aneurysm. Aorta completely covered with a calcified and ulcerated plaque with small mural thrombi (an excellent depiction of proximal suture line)
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| Image:Aortic aneurysm 48.jpg|Dissecting Aneurysm: Gross natural color descending aorta opened into false channel
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 49.jpg|Abdominal Aneurysm: Gross, natural color, unopened specimen with about a six centimeter aneurysm between renals and bifurcation (a very good example of opened aneurysm)
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| Image:Aortic aneurysm 50.jpg|Abdominal Aneurysm: Gross, natural color, an opened aneurysm showing quite well laminated thrombus
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| Image:Aortic aneurysm 51.jpg|Atherosclerosis with Mural Thrombi: Gross, natural color, a nice photo of descending thoracic aorta with extensive ulcerated plaques and mural thrombi in distal portion. The case also has an abdominal aneurysm
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 52.jpg|Pseudoaneurysm Ruptured Into Duodenum: Gross natural color aorta and duodenum with arrow pointing to rupture point of aortobifemoral bypass pseudoaneurysm rupture and another in duodenum a very good demonstration of this very well known complication of aortic prostheses
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| Image:Aortic aneurysm 53.jpg|Abdominal Aneurysm: Gross, natural color, large aneurysm opened showing sessile calcified plaques with no mural thrombus. Lesion extends from renal arteries to the bifurcation (the same lesion seen externally with focus of rupture)
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| Image:Aortic aneurysm 54.jpg|Abdominal Aneurysm Ruptured: Gross, natural color, external view with large area of apparent rupture. Aorta is opened to show this aneurysm)
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 55.jpg|Abdominal Aneurysm: Gross, natural color, unopened large and quite typical aneurysm extending from below renal arteries to bifurcation
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| Image:Aortic aneurysm 56.jpg|Abdominal Aneurysm: Gross, natural color, opened aneurysm with well shown and typical laminated thrombus (external view)
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| Image:Aortic aneurysm 57.jpg|Aortobifemoral Prosthesis: Gross, natural color, nice dissection showing Dacron prosthesis replacing abdominal segment of aorta with portion of atherosclerotic aneurysm with renal arteries and kidneys
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 58.jpg|Aortobifemoral Prosthesis: Gross natural color close-up view of nicely dissected prosthesis extending from below renals to common iliac arteries portion of atherosclerotic aneurysm behind prosthesis
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| Image:Aortic aneurysm 59.jpg|Dissecting Aneurysm: Gross natural color close-up view of aortic valve and proximal aortic arch with ruptured intima rather good illustration of this lesion
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| Image:Aortic aneurysm 60.jpg|Syphilitic Aneurysm: Gross natural color rather a close-up view and outstanding photo of aneurysm ruptured into the left main stem bronchus
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Aortic aneurysm 61.jpg|Syphilitic Aneurysm: Gross natural color typical tree barking in aorta aneurysm opening is seen in which is a thrombus aneurysm ruptured into left main stem bronchus (shown very well)
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| Image:Aortic aneurysm 62.jpg|Dissecting Aneurysm Chronic: Gross natural color first portion of aortic arch with intimal rent well shown with healed margins and view into false channel that shows a surface looking like atherosclerosis which is known to develop in a chronic dissection
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| Image:Aortic aneurysm 63.jpg|Dissecting Aneurysm Chronic: Gross, natural color, closer view of the previous one (a very good example)
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| </gallery>
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| </div>
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| ==Videos on Abdominal Aortic Aneurysm==
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| <youtube v=Sb1bM8MnpRk/>
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| <youtube v=9XPPbWsrtRA/>
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| <youtube v=ovGI2fYc_U8/>
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| ==References==
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| {{Reflist|2}}
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| == Acknowledgements ==
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| The content on this page was first contributed by: [[C. Michael Gibson]] M.S., M.D.
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| {{Circulatory system pathology}}
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