P2RX2
| Purinergic receptor P2X, ligand-gated ion channel, 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | P2RX2 ; MGC129601; P2X2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 14251 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE P2RX2 221372 s at tn.png | |||||||||||
| File:PBB GE P2RX2 221356 x at tn.png | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
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Purinergic receptor P2X, ligand-gated ion channel, 2, also known as P2RX2, is a human gene.[1]
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.[1]
See also
References
Further reading
- North RA (2002). "Molecular physiology of P2X receptors". Physiol. Rev. 82 (4): 1013–67. doi:10.1152/physrev.00015.2002. PMID 12270951.
- Barrera NP, Ormond SJ, Henderson RM; et al. (2005). "Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize". J. Biol. Chem. 280 (11): 10759–65. doi:10.1074/jbc.M412265200. PMID 15657042.
- Mason HS, Bourke S, Kemp PJ (2005). "Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species". Mol. Pharmacol. 66 (6): 1525–35. doi:10.1124/mol.104.000851. PMID 15331767.
- Aschrafi A, Sadtler S, Niculescu C; et al. (2004). "Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes". J. Mol. Biol. 342 (1): 333–43. doi:10.1016/j.jmb.2004.06.092. PMID 15313628.
- Boué-Grabot E, Emerit MB, Toulmé E; et al. (2004). "Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels". J. Biol. Chem. 279 (8): 6967–75. doi:10.1074/jbc.M307772200. PMID 14660627.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Järlebark LE, Housley GD, Raybould NP; et al. (2003). "ATP-gated ion channels assembled from P2X2 receptor subunits in the mouse cochlea". Neuroreport. 13 (15): 1979–84. PMID 12395104.
- Khakh BS, Zhou X, Sydes J; et al. (2000). "State-dependent cross-inhibition between transmitter-gated cation channels". Nature. 406 (6794): 405–10. doi:10.1038/35019066. PMID 10935636.
- Lynch KJ, Touma E, Niforatos W; et al. (1999). "Molecular and functional characterization of human P2X(2) receptors". Mol. Pharmacol. 56 (6): 1171–81. PMID 10570044.
- Brändle U, Spielmanns P, Osteroth R; et al. (1997). "Desensitization of the P2X(2) receptor controlled by alternative splicing". FEBS Lett. 404 (2–3): 294–8. PMID 9119082.
- Lewis C, Neidhart S, Holy C; et al. (1995). "Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons". Nature. 377 (6548): 432–5. doi:10.1038/377432a0. PMID 7566120.
- Brake AJ, Wagenbach MJ, Julius D (1994). "New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor". Nature. 371 (6497): 519–23. doi:10.1038/371519a0. PMID 7523952.
External links
- P2RX2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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