GRIN2C

Glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Identifiers
Symbols	GRIN2C ; NMDAR2C; NR2C
External IDs	Template:OMIM5 Template:MGI HomoloGene: 647
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glutamate receptor, ionotropic, N-methyl D-aspartate 2C, also known as GRIN2C, is a human gene.

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).

See also

• Glutamate receptor
• NMDA receptor

Further reading

• Schröder HC, Perovic S, Kavsan V; et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity". Microbes Infect. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.CS1 maint: Multiple names: authors list (link)
• Monyer H, Sprengel R, Schoepfer R; et al. (1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science. 256 (5060): 1217–21. PMID 1350383.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–40. PMID 7569905.CS1 maint: Multiple names: authors list (link)
• Magnuson DS, Knudsen BE, Geiger JD; et al. (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takano H, Onodera O, Tanaka H; et al. (1994). "Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel". Biochem. Biophys. Res. Commun. 197 (2): 922–6. PMID 8267632.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lannuzel A, Lledo PM, Lamghitnia HO; et al. (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci. 7 (11): 2285–93. PMID 8563977.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Corasaniti MT, Melino G, Navarra M; et al. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. 4 (3): 315–21. PMID 8581564.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS. 10 (5): 463–8. PMID 8724036.CS1 maint: Multiple names: authors list (link)
• Wu P, Price P, Du B; et al. (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons". Neuroreport. 7 (5): 1045–9. PMID 8804048.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bennett BA, Rusyniak DE, Hollingsworth CK (1996). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures". Brain Res. 705 (1–2): 168–76. PMID 8821747.CS1 maint: Multiple names: authors list (link)
• Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine". Brain Res. 706 (2): 303–7. PMID 8822372.CS1 maint: Multiple names: authors list (link)
• Dreyer EB, Lipton SA (1996). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid". Eur. J. Neurosci. 7 (12): 2502–7. PMID 8845955.
• Raber J, Toggas SM, Lee S; et al. (1997). "Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase". Virology. 226 (2): 362–73. doi:10.1006/viro.1996.0664. PMID 8955056.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin YJ, Bovetto S, Carver JM, Giordano T (1997). "Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery". Brain Res. Mol. Brain Res. 43 (1–2): 57–64. PMID 9037519.CS1 maint: Multiple names: authors list (link)
• Kalsi G, Whiting P, Bourdelles BL; et al. (1998). "Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels". Genomics. 47 (3): 423–5. doi:10.1006/geno.1997.5132. PMID 9480759.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–72. doi:10.1006/mcne.1998.0679. PMID 9647694.CS1 maint: Multiple names: authors list (link)
• New DR, Maggirwar SB, Epstein LG; et al. (1998). "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism". J. Biol. Chem. 273 (28): 17852–8. PMID 9651389.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Daggett LP, Johnson EC, Varney MA; et al. (1998). "The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression". J. Neurochem. 71 (5): 1953–68. PMID 9798920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• GRIN2C+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.