FCRL3

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Fc receptor-like 3
Identifiers
Symbols FCRL3 ; FCRH3; IFGP3; IRTA3; SPAP2
External IDs Template:OMIM5 Template:MGI HomoloGene: 76447
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Fc receptor-like 3, also known as FCRL3, is a human gene.[1]

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: FCRL3 Fc receptor-like 3".

Further reading

  • Davis RS, Dennis G, Kubagawa H, Cooper MD (2002). "Fc receptor homologs (FcRH1-5) extend the Fc receptor family". Curr. Top. Microbiol. Immunol. 266: 85–112. PMID 12014205.
  • Davis RS, Wang YH, Kubagawa H, Cooper MD (2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9772–7. doi:10.1073/pnas.171308498. PMID 11493702.
  • Miller I, Hatzivassiliou G, Cattoretti G; et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood. 99 (8): 2662–9. PMID 11929751.
  • Xu MJ, Zhao R, Cao H, Zhao ZJ (2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. PMID 12051764.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Kochi Y, Yamada R, Suzuki A; et al. (2005). "A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities". Nat. Genet. 37 (5): 478–85. doi:10.1038/ng1540. PMID 15838509.
  • Simmonds MJ, Heward JM, Carr-Smith J; et al. (2006). "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease". J. Clin. Endocrinol. Metab. 91 (3): 1056–61. doi:10.1210/jc.2005-1634. PMID 16384851.
  • Eyre S, Bowes J, Potter C; et al. (2007). "Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?". Arthritis Res. Ther. 8 (4): R117. doi:10.1186/ar2006. PMID 16859508.
  • Umemura T, Ota M, Yoshizawa K; et al. (2007). "Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis". Clin. Immunol. 122 (3): 338–42. doi:10.1016/j.clim.2006.08.012. PMID 17020818.
  • Schäfer N, Blaumeiser B, Becker T; et al. (2007). "Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata". Int. J. Immunogenet. 33 (6): 393–5. doi:10.1111/j.1744-313X.2006.00633.x. PMID 17117947.
  • Newman WG, Zhang Q, Liu X; et al. (2007). "Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population". Arthritis Rheum. 54 (12): 3820–7. doi:10.1002/art.22270. PMID 17133579.
  • Choi CB, Kang CP, Seong SS; et al. (2007). "The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans". Arthritis Rheum. 54 (12): 3838–41. doi:10.1002/art.22248. PMID 17133581.
  • Owen CJ, Kelly H, Eden JA; et al. (2007). "Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association". J. Clin. Endocrinol. Metab. 92 (3): 1106–11. doi:10.1210/jc.2006-2183. PMID 17200162.
  • Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841.
  • Martínez A, Núñez C, Martín MC; et al. (2007). "Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD". Tissue Antigens. 69 (4): 313–7. doi:10.1111/j.1399-0039.2007.00816.x. PMID 17389014.
  • Martínez A, Mas A, de Las Heras V; et al. (2007). "FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity?". J. Neuroimmunol. 189 (1–2): 132–6. doi:10.1016/j.jneuroim.2007.06.018. PMID 17617473.

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