FCRL3

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
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Wikidata
View/Edit Human

Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.

Interactions

FCRL3 has been shown to interact with PTPN6.

Further reading

• Miller I, Hatzivassiliou G, Cattoretti G, et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood. 99 (8): 2662–9. doi:10.1182/blood.V99.8.2662. PMID 11929751.
• Xu MJ, Zhao R, Cao H, Zhao ZJ (2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. PMID 12051764.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kochi Y, Yamada R, Suzuki A, et al. (2005). "A functional variant in FcRH3, encoding Fc Receptor Homolog 3, is associated with rheumatoid arthritis and several autoimmunities". Nat. Genet. 37 (5): 478–85. doi:10.1038/ng1540. PMC 1362949. PMID 15838509.
• Simmonds MJ, Heward JM, Carr-Smith J, et al. (2006). "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease". J. Clin. Endocrinol. Metab. 91 (3): 1056–61. doi:10.1210/jc.2005-1634. PMID 16384851.
• Eyre S, Bowes J, Potter C, et al. (2007). "Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?". Arthritis Research & Therapy. 8 (4): R117. doi:10.1186/ar2006. PMC 1779391. PMID 16859508.
• Umemura T, Ota M, Yoshizawa K, et al. (2007). "Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis". Clin. Immunol. 122 (3): 338–42. doi:10.1016/j.clim.2006.08.012. PMID 17020818.
• Schäfer N, Blaumeiser B, Becker T, et al. (2007). "Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata". Int. J. Immunogenet. 33 (6): 393–5. doi:10.1111/j.1744-313X.2006.00633.x. PMID 17117947.
• Newman WG, Zhang Q, Liu X, et al. (2007). "Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population". Arthritis Rheum. 54 (12): 3820–7. doi:10.1002/art.22270. PMID 17133579.
• Choi CB, Kang CP, Seong SS, et al. (2007). "The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans". Arthritis Rheum. 54 (12): 3838–41. doi:10.1002/art.22248. PMID 17133581.
• Owen CJ, Kelly H, Eden JA, et al. (2007). "Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association". J. Clin. Endocrinol. Metab. 92 (3): 1106–11. doi:10.1210/jc.2006-2183. PMID 17200162.
• Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841.
• Martínez A, Núñez C, Martín MC, et al. (2007). "Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD". Tissue Antigens. 69 (4): 313–7. doi:10.1111/j.1399-0039.2007.00816.x. PMID 17389014.
• Martínez A, Mas A, de Las Heras V, et al. (2007). "FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity?". J. Neuroimmunol. 189 (1–2): 132–6. doi:10.1016/j.jneuroim.2007.06.018. PMID 17617473.