CHRNA5

Cholinergic receptor, nicotinic, alpha 5
Identifiers
Symbols	CHRNA5 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55485
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cholinergic receptor, nicotinic, alpha 5, also known as CHRNA5, is a human gene.

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. See MIM 118508 for additional background information on AChRs.[supplied by OMIM]

See also

• Nicotinic acetylcholine receptor

Further reading

• Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol. 147: 1–46. doi:10.1007/s10254-003-0005-1. PMID 12783266.CS1 maint: Multiple names: authors list (link)
• Anand R, Lindstrom J (1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. PMID 1505988.
• Chini B, Clementi F, Hukovic N, Sher E (1992). "Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines". Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1572–6. PMID 1542648.CS1 maint: Multiple names: authors list (link)
• Raimondi E, Rubboli F, Moralli D; et al. (1992). "Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits". Genomics. 12 (4): 849–50. PMID 1572664.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–82. PMID 2004777.CS1 maint: Multiple names: authors list (link)
• Elliott KJ, Ellis SB, Berckhan KJ; et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. PMID 8906617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. PMID 9009220.
• Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand). 43 (3): 433–42. PMID 9193799.CS1 maint: Multiple names: authors list (link)
• Gerzanich V, Wang F, Kuryatov A, Lindstrom J (1998). "alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors". J. Pharmacol. Exp. Ther. 286 (1): 311–20. PMID 9655874.CS1 maint: Multiple names: authors list (link)
• Lentz TL (2000). "Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits". Biochem. Biophys. Res. Commun. 268 (2): 480–4. doi:10.1006/bbrc.2000.2155. PMID 10679230.
• Groot-Kormelink PJ, Boorman JP, Sivilotti LG (2001). "Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach". Br. J. Pharmacol. 134 (4): 789–96. doi:10.1038/sj.bjp.0704313. PMID 11606319.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Soldà G, Boi S, Duga S; et al. (2005). "In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs". Gene. 345 (2): 155–64. doi:10.1016/j.gene.2004.12.005. PMID 15716100.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• CHRNA5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.