Complex regional pain syndrome pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
The pathophysiology of CRPS remains unclear. However, recent research has suggested that oxidative damage (e.g. by free radicals) associated with one of the precipitating factors described earlier may play a role.[1]
Susceptibility
CRPS can strike at any age, but is more common between the ages of 40 and 60. It affects both men and women, but is more frequently seen in women. The number of reported CRPS cases among adolescents and young adults is increasing.
Investigators estimate that two to five percent of those with peripheral nerve injury and 12 to 21 percent of those with hemiplegia (paralysis of one side of the body) will suffer from CRPS.
Research has demonstrated that the administration of Vitamin C after an injury may decrease one's susceptibility to developing CRPS.[1]