Sodium valproate

Sodium valproate
Clinical data
Pregnancy; category	AU: D ; US: D (Evidence of risk) ; ;
Routes of; administration	Oral, i.v.
ATC code	N03AG01 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Protein binding	90–95%
Metabolism	75% by CYP enzymes
Elimination half-life	9–18 hours
Excretion	20% excreted as glucuronide
Identifiers
	IUPAC name sodium 2-propylpentanoate;
CAS Number	1069-66-5;
PubChem CID	14047;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C8H15NaO2
Molar mass	166.20 g/mol

Sodium valproate (INN) or valproate sodium (USAN) is the sodium salt of valproic acid and is an anticonvulsant used in the treatment of epilepsy and bipolar disorder, as well as other psychiatric conditions requiring the administration of a mood stabilizer. The intravenous formulations are used when oral administration is not possible.

Formulations

Trade names are in bold, followed by the manufacturer.

U.S.

Intravenous injection – Depacon by Abbott Laboratories.
Syrup – Depakene by Abbott Laboratories. (Note Depakene capsules are valproic acid).

UK and Australia

Tablets – Orlept by Wockhardt and Epilim by Sanofi-Aventis.
Oral solution – Orlept Sugar Free by Wockhardt and Epilim by Sanofi-Aventis.
Syrup – Epilim by Sanofi-Aventis.
Intravenous injection – Epilim Intravenous by Sanofi-Aventis.
Extended release tablets – Epilim Chrono by Sanofi-Aventis. A combination of sodium valproate and valproic acid in a 2.3:1 ratio.
Enteric-coated tablets – Epilim EC200 by Sanofi-synthélabo. A 200 mg sodium valproate enteric-coated tablet.

Germany, Switzerland, Norway

Tablets – Orfiril by Desitin Pharmaceuticals
Intravenous injection – Orfiril IV by Desitin Pharmaceuticals

South Africa

Syrup – Convulex by Byk Madaus

Canada

Intravenous injection – Epival or Epiject by Abbott Laboratories.
Syrup – Depakene by Abbott Laboratories. Generic formulations include Apo-Valproic and ratio-Valproic.

Others

In much of Europe, Depakine and Depakine Chrono are equivalent to Epilim and Epilim Chrono above.

External links

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