Torsemide detailed information

Torsemide detailed information

Clinical data
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral, IV
ATC code	C03CA04 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	Highly bound (>99%).
Metabolism	Hepatic (80%)
Elimination half-life	3.5 hours; Cirrhosis: 7-8 hours
Identifiers
IUPAC name 1-[4-(3-methylphenyl) aminopyridin-3-yl] sulfonyl-3-propan-2-yl-urea
CAS Number	56211-40-6
PubChem CID	41781
DrugBank	APRD00217
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C16H20N4O3S
Molar mass	348.421 g/mol
3D model (JSmol)	Interactive image
SMILES CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2

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Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonylurea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex.

Compared to other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium-loss. There is no evidence of torasemide-induced ototoxicity demonstrated in humans (Dunn et al., 1995).

References

• Dunn CJ, Fitton A, Brogden RN. Torasemide. An update of its pharmacological properties and therapeutic efficacy. Drugs. 1995 Jan;49(1):121-42. PMID 7705212

External links

• Medlineplus drug information: Torsemide (Systemic) – information from USP DI Advice for the Patient