Fibroadenoma other diagnostic studies

Jump to navigation Jump to search

Fibroadenoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Fibroadenoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

CT Scan

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Fibroadenoma other diagnostic studies On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Fibroadenoma other diagnostic studies

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Fibroadenoma other diagnostic studies

CDC on Fibroadenoma other diagnostic studies

Fibroadenoma other diagnostic studies in the news

Blogs on Fibroadenoma other diagnostic studies

Directions to Hospitals Treating Fibroadenoma

Risk calculators and risk factors for Fibroadenoma other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

The definitive diagnosis of fibroadenoma is confirmed by an ultrasound guided biopsy. Characteristic findings for fibroadenoma on microscopic histopathological analysis can be found here.[1]

Other Diagnostic Studies

Aspiration Cytology

  • The definitive diagnosis of fibroadenoma is confirmed by an ultrasound guided biopsy. Characteristic findings for fibroadenoma on microscopic histopathological analysis can be found here.[1]
  • In combination with clinical diagnosis of fibroadenoma, fine needle aspiration (FNA) can improve the sensitivity of the diagnosis to 86%, with a specificity of 76%.[2]
  • Aspiration cytology may confuse fibroadenomas with other benign breast lesions, false diagnosis of a malignant process is uncommmon.[2]
  • Indications for an ultrasound guided biopsy include:[3]
  • Rapidly enlarging mass
  • Atypical findings on ultrasound such as non-circumscribed margins, complex solid and cystic components, posterior acoustic shadowing,
  • A lesion greater than 3 cm in size, with no previous studies for comparison
  • Patients preference
  • History of a risk factor for malignancy regardless of the lesion having a benign appearance on ultrasonography. Examples include a prior chest irradiation, known concurrent cancer not involving the breast, family history of breast cancer.
  • The characteristic cytologic features of fibroadenomas include:[2]
  • Clusters of spindle cells without inflammatory or fat cells. This is found in 96% of all fibroadenomas.
  • Aggregates of cells with a papillary configuration resembling elk antler (antler horn clusters). Found in about 93%.
  • Uniform cells with well-defined cytoplasm lying in rows and columns (honeycomb sheets). Found in about 95%
  • A "triple assessment approach" refers to the combination of clinical breast examination, imaging and percutaneous tissue study. This approach allows a 95% accurate differentiation between a benign and malignant lesion.[4]


Vacuum-Assisted Ultrasound Guided Biopsy

  • It involves usage of a hollow bore needle to make multiple percutaneous passes (under ultrasound or stereotactic guidance) with subsequent aspiration of the breast tissue via vacuum suction.[5]
  • The procedure is said to be complete when the mass appears to be radiographically removed completely (judging via radiographic guidance).[5]
  • Most patients that undergo this procedure are more satisfied with the cosmetic outcome when compared to patients that undergo conventional open excision.

[6]

References

  1. 1.0 1.1 Fibroadenoma. Radiopaedia (2015) http://radiopaedia.org/articles/fibroadenoma-of-the-breast-1 Accessed on January, 29 2016
  2. 2.0 2.1 2.2 Greenberg R, Skornick Y, Kaplan O (September 1998). "Management of breast fibroadenomas". J Gen Intern Med. 13 (9): 640–5. PMC 1497021. PMID 9754521.
  3. Lee EJ, Chang YW, Oh JH, Hwang J, Hong SS, Kim HJ (2018). "Breast Lesions in Children and Adolescents: Diagnosis and Management". Korean J Radiol. 19 (5): 978–991. doi:10.3348/kjr.2018.19.5.978. PMC 6082765. PMID 30174488.
  4. Sperber F, Blank A, Metser U, Flusser G, Klausner JM, Lev-Chelouche D (2003). "Diagnosis and treatment of breast fibroadenomas by ultrasound-guided vacuum-assisted biopsy". Arch Surg. 138 (7): 796–800. doi:10.1001/archsurg.138.7.796. PMID 12860764.
  5. 5.0 5.1 Lee M, Soltanian HT (2015). "Breast fibroadenomas in adolescents: current perspectives". Adolesc Health Med Ther. 6: 159–63. doi:10.2147/AHMT.S55833. PMC 4562655. PMID 26366109.
  6. Lakoma A, Kim ES (2014). "Minimally invasive surgical management of benign breast lesions". Gland Surg. 3 (2): 142–8. doi:10.3978/j.issn.2227-684X.2014.04.01. PMC 4115760. PMID 25083508.

Template:WH Template:WS