Hereditary nonpolyposis colorectal cancer historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
Lynch syndrome was first described by Dr. Henry T. Lynch, an American physician, in 1966.[1]
Overview
Historical Perspective
Discovery
- There is limited information about the historical perspective of [disease name].
OR
- [Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].
- The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
- In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
- In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
Landmark Events in the Development of Treatment Strategies
Impact on Cultural History
Famous Cases
The following are a few famous cases of [disease name]:
Historical Perspective
- In 1966, Dr. Henry T. Lynch characterized Lynch syndrome for the first time.[2]
- Dr. Lynch discovered hereditary nonpolyposis colorectal cancer, as the most common form of hereditary colorectal cancer.
- In his earlier work, he described the disease entity as "cancer family syndrome". He demonstrated the Mendelian inheritance pattern for certain breast and ovarian cancers, which laid the ground work for the identification of specific genes responsible for these familial cancers, such as BRCA1 and BRCA2.[3]
- In 1971, Lynch and Krush updated the studies of the family, in which the disease eventually became known as hereditary nonpolyposis colon cancer (HNPCC), also known as Lynch Syndrome.[4]
- The term "Lynch syndrome" was coined in 1984 by other authors; Lynch named the condition hereditary nonpolyposis colorectal cancer in 1985. Since then the two terms have been used interchangeably, until later advances in the understanding of the genetics of the disease led to the term hereditary nonpolyposis colorectal cancer falling out of favor.[5]
- Other sources reserve the term "Lynch syndrome" when there is a known DNA mismatch repair defect, and use the term "familial colorectal cancer type X" when the Amsterdam criteria are met but there is no known DNA mismatch repair defect.[6]
References
- ↑ Lynch HT, Lynch JF (1985). "Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II): a common genotype linked to oncogenes?". Med. Hypotheses. 18 (1): 19–28. PMID 4069033.
- ↑ Lynch HT, Shaw MW, Magnuson CW, Larsen AL, Krush AJ (Feb 1966). "Hereditary factors in cancer. Study of two large midwestern kindreds". Archives of Internal Medicine. 117 (2): 206–12. doi:10.1001/archinte.117.2.206. PMID 5901552.
- ↑ Henry. T Lynch.Wikipedia https://en.wikipedia.org/wiki/Henry_T._Lynch Accessed on December 01, 2015
- ↑ Schlussel AT, Gagliano RA, Seto-Donlon S, Eggerding F, Donlon T, Berenberg J; et al. (2014). "The evolution of colorectal cancer genetics-Part 1: from discovery to practice". J Gastrointest Oncol. 5 (5): 326–35. doi:10.3978/j.issn.2078-6891.2014.069. PMC 4173047. PMID 25276405.
- ↑ Bellizzi AM, Frankel WL (Nov 2009). "Colorectal cancer due to deficiency in DNA mismatch repair function: a review". Advances in Anatomic Pathology. 16 (6): 405–17. doi:10.1097/PAP.0b013e3181bb6bdc. PMID 19851131.
- ↑ Lindor NM (Oct 2009). "Familial colorectal cancer type X: the other half of hereditary nonpolyposis colon cancer syndrome". Surgical Oncology Clinics of North America. 18 (4): 637–45. doi:10.1016/j.soc.2009.07.003. PMC 3454516. PMID 19793571.