Acute myeloid leukemia physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Carlos A Lopez, M.D. [3] Shyam Patel [4]

Overview

Common physical examination findings of acute myeloid leukemia include anemia, fever, pallor, Leukemia cutis, bruising, petechiae, ecchymosis and tachycardia.

Physical Examination

Appearance

The patient may appear pale because of anemia.[1]


Vitals

Skin

Head

Nose

Heart

Abdomen

Extremities

  • Bone tenderness
  • Joint tenderness

Neurologic

  • Altered mental status if there is central nervous system involvement[2]
  • Nuchal rigidity if there is leptomeningeal involvement
  • Headache if leukostasis is present
  • Blurred vision[3]

References

  1. 1.0 1.1 Zhang Z, Zou J, Li Y, Liu Z, Xu R, Tian W; et al. (2015). "Clinical characteristics and laboratory analyses of acute myeloid leukemia with t(16;21)(p11;q22)". Oncol Lett. 9 (5): 2244–2248. doi:10.3892/ol.2015.3051. PMC 4467340. PMID 26137050.
  2. Laningham FH, Kun LE, Reddick WE, Ogg RJ, Morris EB, Pui CH (2007). "Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae". Neuroradiology. 49 (11): 873–88. doi:10.1007/s00234-007-0300-7. PMC 2386669. PMID 17924103.
  3. Patel SA (2016). "Acute Myeloid Leukemia Relapse Presenting as Complete Monocular Vision Loss due to Optic Nerve Involvement". Case Rep Hematol. 2016: 3794284. doi:10.1155/2016/3794284. PMC 5030445. PMID 27668104.

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