Hemophilia A risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fahd Yunus, M.D. [2]

Overview

Risk factors for development of Hemophilia A and B include being of male sex and having a positive family history of the disease.

It is of note that acquired forms of the disease occur in specific circumstances including Malignancies, Pregnancy, Autoimmune disorders, Certain medications; All of which could be considered as Hemophilia risk factor either. 

Risk Factors

Common risk factors in the development of Hemophilia A are:

Best-studied risk factors of the acquired form of the disease include:[2]

  • Malignancies (mostly hematologic)
  • Pregnancy
  • Autoimmune disorders(Lupus erythematosus, Rheumatoid arthritis)
  • Infections(Hepatitis C, AIDS)
  • Certain Drugs consumption (e.g. Interferon-ą)
  • Dermatological conditions(Pemphigus, Psoriasis)

Of note, the majority of reported acquired cases of Hemophilia are about Hemophilia A type. It appears that, the same as congenital form, acquired form of Hemophilia B is rarer than Hemophilia A too.

The remaining cases of acquired Hemophilia are idiopathic or the underlying etiology is not known yet.

References

  1. How Hemophilia is Inherited | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/inheritance-pattern.html. Accessed on Sept 20, 2016
  2. Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L; et al. (2012). "Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2)". J Thromb Haemost. 10 (4): 622–31. doi:10.1111/j.1538-7836.2012.04654.x. PMID 22321904.

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