Chronic myelogenous leukemia staging
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Chronic myelogenous leukemia may be classified according to the clinical characteristics and laboratory findings into five subtypes: chronic phase, accelerated phase, and blast crisis.
Phases of chronic myelogenous leukemia
The phase of chronic myelogenous leukemia refers to the aggressiveness of the disease. Your doctor determines the phase by measuring the proportion of diseased cells to healthy cells in your blood or bone marrow. A higher proportion of diseased cells means chronic myelogenous leukemia is at a more advanced stage.
Phases of chronic myelogenous leukemia include:
- Chronic. The chronic phase is the earliest phase and generally has the best response to treatment.
- Accelerated. The accelerated phase is a transitional phase when the disease becomes more aggressive.
- Blastic. Blastic phase is a severe, aggressive phase that becomes life-threatening.
Relapsed CML
Relapsed, or recurrent, CML means that the number of blast cells in the blood and bone marrow increase after treatment and reaching remission. Remission means that the blood cell counts have returned to normal and stay at or near normal levels for long periods of time.
Refractory
Refractory disease means the leukemia did not respond to treatment.
Read more: http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/staging/?region=ab#ixzz5FHse2ARz
Classification
Chronic myelogenous leukemia is often divided into five phases based on clinical characteristics and laboratory findings.[1][2]
References
- ↑ Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/staging/?region=ab
- ↑ Vardiman J, Harris N, Brunning R (2002). "The World Health Organization (WHO) classification of the myeloid neoplasms". Blood. 100 (7): 2292–302. PMID 12239137. Retrieved 2007-09-22.