Gastrointestinal stromal tumor historical perspective
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- Earlier gastrointestinal stromal tumors were classified as smooth muscle tumors such as leiomyomas or leiomyosarcomas. However, with the use of electron microscopy gave little evidence in the favour of smooth muscle cells as origin of GIST.
- In 1980s, the use of immunohistochemistry and immunotyping further suggested that GIST arise from antigens related to neural crest cells.
In 1983, Mazur and Clark and Schaldenbrand and Appleman in 1984 were the first to describe gastrointestinal stromal tumors as an independent entity.
The term gastrointestinal stromal tumors was initially coined as a purely descriptive term by Mazur and Clark in 1983 to define intra-abdominal tumors that were not carcinomas (i.e., nonepithelial tumors) and that also did not exhibit histologic features of smooth muscle or nerve cells.[1]