Mesenteric ischemia risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Feham Tariq, MD [2]

Overview

Risk Factors

The following conditions pose a signifiacnt risk towards the development of mesenteric ischemia either by interrupting the blood flow through the artery or vein supplying the small intestine (e.g.thromboemboli) or by reducing the blood supply (e.g. vasoconstriction). Also, there are certain life-style related risk factors which predominantly cause mesenteric ischemia in the older age group. [1][2][3]

Risk factors
Occlusive Embolic Atrial fibrillation
Cardiac arrhythmia
Valvular heart disease
Infective endocarditis
Recent myocardial infarction
Ventricular aneurysm
Aortic atherosclerosis
Thrombotic Advanced age
Low cardiac output states
Peripheral arterial disease
Traumatic injury
Inherited thrombophilia-
Acquired thrombophilia- malignancy, oral contraceptives intake.
Non-occlusive Heart failure
Aortic insufficiency
Septic shock
Vasoconstrictive drugs:
Cocaine abuse or ergot poisoning
Hemodialysis
Other causes Lifestyle related risk factors:
  • High cholesterol levels
  • History of smoking
  • Immobility
  • Recent surgery

Less common risk factors:

  • Fibromuscular dysplasia
  • Beta receptor blocking agents
  • Hepatitis
  • Common risk factors in the development of mesenteric ischemia include:
    • Occlusive causes
      • Embolic causes:[1]
      • Atrial fibrillation
      • Cardiac arrhythmias
      • Valvular heart diseases
      • Infective endocarditis
      • Recent myocardial infarction
      • Ventricular aneurysm
      • Aortic atherosclerosis
      • Aortic aneurysm
    • Thrombotic causes:[2]
      • Advanced age
      • Low cardiac output states
      • Traumatic injury
      • Peripheral artery disease
  • Non-occlusive causes:[3]

References

  1. 1.0 1.1 Fitzgerald T, Kim D, Karakozis S, Alam H, Provido H, Kirkpatrick J (2000). "Visceral ischemia after cardiopulmonary bypass". Am Surg. 66 (7): 623–6. PMID 10917470.
  2. 2.0 2.1 Martinelli I, Mannucci PM, De Stefano V, Taioli E, Rossi V, Crosti F; et al. (1998). "Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families". Blood. 92 (7): 2353–8. PMID 9746774.
  3. 3.0 3.1 Acosta S, Ogren M, Sternby NH, Bergqvist D, Björck M (2006). "Fatal nonocclusive mesenteric ischaemia: population-based incidence and risk factors". J Intern Med. 259 (3): 305–13. doi:10.1111/j.1365-2796.2006.01613.x. PMID 16476108.