Graft-versus-host disease risk factors
Graft-versus-host disease |
Differentiating Graft-versus-host disease from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
The major risk factor for GvHD is disparity in HLA alleles between the recipient and host.
Risk Factors
Adverse risk factors for GvHD include:
- High degree of HLA disparity between host and donor cells[1]
- Use of unrelated donors as the stem cell source[1]
- Total body irradiation as the conditioning regimen prior to transplant[1]
- Prior acute GvHD[2]
- Use of peripheral blood stem cells[2]
- Use of a T cell replete graft[2]
- Viral infection, since this can contribute to immune activation[2]
- Male host[2]
- Multiparous female donor[2]
Protective risk factors include:
- High degree of HLA concordance between the host and donor
- Use of umbilical cord blood as the donor source (given decreased number of donor T cells)
References
- ↑ 1.0 1.1 1.2 Rezvani AR, Storb RF (2012). "Prevention of graft-vs.-host disease". Expert Opin Pharmacother. 13 (12): 1737–50. doi:10.1517/14656566.2012.703652. PMC 3509175. PMID 22770714.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Socié G, Ritz J (2014). "Current issues in chronic graft-versus-host disease". Blood. 124 (3): 374–84. doi:10.1182/blood-2014-01-514752. PMC 4102710. PMID 24914139.