Hepatoblastoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

Common risk factors in the development of hepatoblastoma are Aicardi syndrome, Beckwith-Wiedemann syndrome, familial adenomatous polyposis, low birth weight infants, and glycogen storage diseases.[1]

Risk Factors

The table below lists risk factors for hepatoblastoma:[1]

Associated Disorder Clinical findings
Aicardi syndrome
  • Agenesis of the corpus callosum, chorioretinal lacunae, and infantile spasms, with a characteristic facies.
Beckwith-Wiedemann syndrome
  • Hemihypertrophy, hemihyperplasia.
Familial adenomatous polyposis
  • Adenoma, hepatoblastoma
Glycogen storage diseases I–IV
  • Symptoms vary by individual disorder.
Low birth weight infants
  • Preterm and small-for-gestation-age neonates.
Simpson-Golabi-Behmel syndrome
  • Macroglossia, macrosomia, renal and skeletal abnormalities, and increased risk of Wilms tumor.
Trisomy 18, other trisomies

References

  1. 1.0 1.1 Risk factors. National Cancer Institute 2015. http://www.cancer.gov/types/liver/hp/child-liver-treatment-pdq#link/_570_toc. Accessed on October 28, 2015


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