B-cell prolymphocytic leukemia overview
B-cell prolymphocytic leukemia |
Differentiating B-cell prolymphocytic leukemia from other Diseases |
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Diagnosis |
Treatment |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Carlos A Lopez, M.D. [2]
Synonyms and keywords: B-PLL, Prolymphocytic leukemia, B-cell type
Overview
B-cell prolymphocytic leukemia is a form of leukemia or cancer of the white blood cells
Historical Perspective
Classification
Pathophysiology
B-cell prolymphocytic leukemia arises from mature B-cells, which are hematologic white cells that are normally involved in the in the humoral immunity component of the adaptive immune system by secreting antibodies.
Differentiating B-cell prolymphocytic leukemia from other Diseases
B-cell prolymphocytic leukemia must be differentiated from other diseases such as T-cell prolymphocytic leukemia, chronic lymphocytic leukemia and hairy cell leukemia.
Epidemiology and Demographics
The incidence of B-cell prolymphocytic leukemia is 1% of lymphocytic leukemias. B-cell prolymphocytic leukemia affects men and women equally.
Risk Factors
Screening
Natural History, Complications and Prognosis
The prognosis for B-cell prolymphocytic leukemia is generally poor.
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | CT | MRI | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies