Disseminated intravascular coagulation causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
There are a variety of causes of DIC[1], all usually causing the release of chemicals into the blood that instigates the coagulation.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Disseminated intravascular coagulation in itself is a life-threatening condition and must be treated as such irrespective of the cause.
Common Causes
- Infections:
- Sepsis, particularly with gram-negative bacteria
- Viral
- Malaria
- Rickettsial
- Obstetric complications (most common cause), with chemicals from the uterus being released into the blood. These include:
- Amniotic fluid embolism
- Eclampsia
- Abruptio placentae
- Placenta praevia
- intra-uterine death
- Tissue trauma such as burns, accidents, surgery, heat stroke or shock.
- Liver disease:
- Incompatible blood transfusion reactions or massive blood transfusion (when more than the total circulatory volume is tranfused)
- Graft-versus-host disease
- Cancers, particularly of the following types, and especially when metastatic:
- Viral hemorrhagic fevers bring about their frank effects, paradoxically, by causing DIC.
- Envenomation by some species of venomous snakes, such as those belonging to the genus Echis (saw-scaled vipers).
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ Ledingham, J (2000). Concise Oxford Textbook of Medicine. Oxford University Press. ISBN 0-19-262870-4, Check
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