Pleomorphic adenoma historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Pleomorphic adenoma was first described by Minssen in 1874 in a monograph named Ahlbom's. Later Mark and Dahlenfors in 1986 and Bullerdiek et al. in 1987 found some clonal chromosome abnormalities that are related to pleomorphic adenoma.

Historical Perspective

Discovery

  • In 1874, Minssen was the first to describe in detail about pleomorphic adenoma in monograph named Ahlbom's.[1]
  • Later in 1986, Mark and Dahlenfors found some clonal chromosome abnormalities related to pleomorphic adenoma, with a majority them involving 8q12.[2]
  • In 1987 Bullerdiek et al found another subset of tumors characterized by changes affecting 12q13-q15.[3]

Landmark Events in the Development of Treatment Strategies

Impact on Cultural History

Famous Cases

The following are a few famous cases of [disease name]:

References

  1. Ghosh, Swapan Kr.; Saha, Jayanta; Chandra, Sudipta; Datta, Saumyajit (2011). "Pleomorphic Adenoma of the Base of the Tongue––A Case Report". Indian Journal of Otolaryngology and Head & Neck Surgery. 63 (S1): 113–114. doi:10.1007/s12070-011-0136-7. ISSN 2231-3796.
  2. Bullerdiek J, Raabe G, Bartnitzke S, Böschen C, Schloot W (June 1987). "Structural rearrangements of chromosome Nr 8 involving 8q12--a primary event in pleomorphic ademona of the parotid gland". Genetica. 72 (2): 85–92. PMID 3505884.
  3. Bullerdiek J, Bartnitzke S, Weinberg M, Chilla R, Haubrich J, Schloot W (1987). "Rearrangements of chromosome region 12q13----q15 in pleomorphic adenomas of the human salivary gland (PSA)". Cytogenet. Cell Genet. 45 (3–4): 187–90. doi:10.1159/000132452. PMID 3691185.

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