Wild-type (senile) amyloidosis MRI
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
MRI
Cardiovascular Magnetic Resonance (CMR)
- T1 sequence of CMR with the use of gadolinium can differentiate extracellular tissue thickening due to myocardial hypertrophy vs. extracellular deposition.
- Using pre- and post-contrast T1 mapping, extracellular volume (ECV) can be calculated, which is a direct measurement of the cardiac interstitium.[1]
- ECV expansion is a quantitative marker of the amyloid burden and can detect amyloid fibrils infiltration earlier than conventional testing.
References
- ↑ Francois-Pierre Mongeon, Michael Jerosch-Herold, Otavio Rizzi Coelho-Filho, Ron Blankstein, Rodney H. Falk & Raymond Y. Kwong (2012). "Quantification of extracellular matrix expansion by CMR in infiltrative heart disease". JACC. Cardiovascular imaging. 5 (9): 897–907. doi:10.1016/j.jcmg.2012.04.006. PMID 22974802. Unknown parameter
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