Polymyositis and dermatomyositis pathophysiology

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Polymyositis and dermatomyositis Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

The exact pathogenesis of polymyositis and dermatomyositis is not fully understood.

Pathophysiology

Pathogenesis

  • Polymyositis is caused by inflammation and degeneration of the muscles. Dermatomyositis is caused by skin inflammation.
  • The exact pathogenesis of polymyositis and dermatomyositis is not fully understood. However, it is understood that polymyositis and dermatomyositis are the result of autoimmune attack but triggering factors of are not well-known.

Antisynthetase syndrome

Amyopathic dermatomyositis

Genetics

  • [Disease name] is transmitted in [mode of genetic transmission] pattern.
  • Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
  • The development of [disease name] is the result of multiple genetic mutations.

Associated Conditions

Different conditions associated with polymyositis and dermatomyositis include:

Gross Pathology

  • On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

Microscopic Pathology

  • On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

References