Retinoblastoma differential diagnosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1],Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Retinoblastoma must be differentiated from other diseases that cause leukocoria such as congenital cataract, persistent fetal vasculature, Coats disease, coloboma of choroid or optic disc, toxocariasis, astrocytic hamartoma, retinopathy of prematurity, vitreous hemorrhage, uveitis, retinal dysplasia, and medulloepithelioma.[1]
Differential diagnosis
Retinoblastoma must be differentiated from other diseases that cause leukocoria. The common causes of leukocoria in children include:[1]
- Congenital cataract
- Persistent fetal vasculature
- Coats disease
Less common causes of leukocoria include:
- Coloboma of choroid or optic disc
- Toxocariasis
- Astrocytic hamartoma
- Retinopathy of prematurity (stage 4, 5)
- Vitreous hemorrhage
- Uveitis
- Retinal dysplasia
- Medulloepithelioma
Differentiating features of some common and less common differential diagnosis are:
Disease/Condition | Differentiating Signs/Symptoms | Differentiating Tests |
---|---|---|
Congenital Cataract |
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Coats disease (exudative retinitis or retinal telangiectasis) |
|
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Persistent fetal vasculature (formerly known as persistent hyperplastic primary vitreous) |
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|
Retinopathy of prematurity (ROP) |
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|
Ocular toxocariasis |
|
|
Disease | Prominent clinical feature | Radiological findings |
---|---|---|
Ocular cysticercosis |
|
|
Retinal detachment |
|
|
Hyperthyroid Ophthalmopathy |
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|
Retinoblastoma |
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|
References
- ↑ 1.0 1.1 Retinoblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Retinoblastoma#cite_note-30 Accessed on October 2, 2015
- ↑ 2.0 2.1 "How to Diagnose and Manage Coats' Disease".
- ↑ 3.0 3.1 "Management of retinal detachment: a guide for non-ophthalmologists".
- ↑ 4.0 4.1 "Thyroid Ophthalmopathy - EyeWiki".
- ↑ 5.0 5.1 "c.ymcdn.com".