Squamous cell carcinoma of the lung medical therapy
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Squamous Cell Carcinoma of the Lung Microchapters |
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Differentiating Squamous Cell Carcinoma of the Lung from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2] Maria Fernanda Villarreal, M.D. [3]
Overview
Chemotherapy is indicated for non-small cell lung cancer stage (IB, II, and III) as adjuvant therapy. The predominant therapy for non-small cell lung cancer is surgical resection. Chemotherapy and chemoradiation may be required upon histological subtype of non-small cell lung cancer, location, size, and lymph node involvement. Commonly used chemotherapeutic agents, include: gemcitabine, paclitaxel, docetaxel, pemetrexed, etoposide or vinorelbine.
Medical Therapy
- Initial medical therapy for patients with squamous cell carcinoma of the lung will depend on molecular testing (presence of genetic mutations)
- Erlotinib is the first-line treatment for patients with squamous cell carcinoma of the lung whose cancer has spread to other parts of the body and that has certain types of epidermal growth factor receptor (EGFR) mutations.
- Chemotherapy regimen by injection, includes:
- Paclitaxel (Abraxane)
- Cisplatin (Platinol-AQ)
- Gemcitabine (Gemzar)
- Carboplatin
- Etoposide (Etopophos)
- Docetaxel (Docefrez)
- Pemetrexed
- Other chemotherapy regimen treatments, include:
- Afatinib
- Erlotinib (Tarceva)
- Gefitinib (Iressa)
- Crizotinib
- Bevacizumab by injection
- Vinorelbine by injection
- Chemotherapy is indicated as adjuvant for stage IB, II, and III squamous cell carcinoma of the lung
- Platinum-based chemotherapy (cisplatin, carboplatin, etoposide, irinotecan) are the mainstay of squamous cell carcinoma of the lung
- Platinum-based chemotherapy consists of four to six cycles
Complications of
- Medical therapy complications for squamous cell carcinoma of the lung will depend on the chemotherapeutic agent.
- Common chemotherapy complications, include:
- Platinum-based chemotherapy
- The main dose-limiting side effect of cancer treatment with platinum compounds, include:
- Other chemotherapeutic agent complications, include: