Squamous cell carcinoma of the lung historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2] Maria Fernanda Villarreal, M.D. [3]

Overview

In 1929, Fritz Lickint, a German physican, first described the association between smoking and squamous cell carcinoma of the lung.

In 1879, Harting and Hesse, two German physicians, first described the association between lung cancer and working in mines.
In 1929, Fritz Lickint a German physican first described the association between smoking and squamous cell carcinoma of the lung.
In 1950, "The British Doctors Study" was the first solid epidemiological evidence of the link between lung cancer and smoking.^[1]
In 1966, the first preventive measures against lung cancer were implemented, warning labels first appear on cigarette packs "Caution: Cigarette Smoking May Be Hazardous to Your Health".^[2]
In 1982, Geoffrey Cooper, an American pathologist, first used the NIH 3T3 focus assay to identify the activated K-RAS oncogene in lung cancer cell lines.^[3]
In 1986, the association between second-hand smoking and squamous cell carcinoma of the lung was established.^[2]
In 1987, researchers first established that epidermal growth factor receptor (EGFR) plays an important role in the growth and spread of squamous cell carcinoma of the lung.^[4]

↑ Miller YE (2005). "Pathogenesis of lung cancer: 100 year report". Am. J. Respir. Cell Mol. Biol. 33 (3): 216–23. doi:10.1165/rcmb.2005-0158OE. PMC 2715312. PMID 16107574.
↑ ^2.0 ^2.1 Witschi H (2001). "A short history of lung cancer". Toxicol. Sci. 64 (1): 4–6. PMID 11606795.
↑ Der CJ, Krontiris TG, Cooper GM (1982). "Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses". Proc. Natl. Acad. Sci. U.S.A. 79 (11): 3637–40. PMC 346478. PMID 6285355.
↑ Timeline of lung cancer. http://cancerprogress.net/timeline/lung-cancer Accessed on February 17, 2016