Langerhans cell histiocytosis epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Langerhans cell histiocytosis is a rare disease that tends to affect children and adolescents. The median age at diagnosis depends on the specific subtype of the disease. The incidence of Langerhans cell histiocytosis is approximately 5 per 1,000,000 individuals in the United States. Males are more commonly affected with Langerhans cell histiocytosis than females. The male to female ratio is approximately 2 to 1. Langerhans cell histiocytosis usually affects Caucasian and Hispanic individuals. African American individuals are less likely to develop Langerhans cell histiocytosis.[1][2][3][4][5]
Epidemiology and Demographics
Prevalence
- Langerhans cell histiocytosis is a rare disease that tends to affect children and adolescents.[1][2][3][4][5]
Incidence
- The incidence of Langerhans cell histiocytosis is approximately 5 per 1,000,000 individuals in the United States.[1][2][3][4][5]
Age
- Langerhans cell histiocytosis commonly affects individuals younger than 15 years of age.[1][2][3][4][5]
- The median age at diagnosis depends on the specific subtype of the disease, such as:
- Pulmonary Langerhans cell histiocytosis is usually first diagnosed among adults.
- Unifocal Langerhans cell histiocytosis and multifocal unisystem Langerhans cell histiocytosis are usually first diagnosed among individuals of 2-10 years of age.
- Multifocal multisystem Langerhans cell histiocytosis is usually first diagnosed among individuals younger than 2 years of age.
Gender
- Males are more commonly affected with Langerhans cell histiocytosis than females. The male to female ratio is approximately 2 to 1.[1][2][3][4][5]
Race
- Langerhans cell histiocytosis usually affects Caucasian and Hispanic individuals. African American individuals are less likely to develop Langerhans cell histiocytosis.[1][2][3][4][5]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 DiCaprio MR, Roberts TT (2014). "Diagnosis and Management of Langerhans Cell Histiocytosis". J Am Acad Orthop Surg. 22 (10): 643–652. doi:10.5435/JAAOS-22-10-643. PMID 25281259.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Langerhans Cell Histiocytosis Treatment (PDQ®): Health Professional Version. National Cancer Institute (2015) http://www.cancer.gov/types/langerhans/hp/langerhans-treatment-pdq Accessed on February, 3 2016
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Grana N (2014). "Langerhans cell histiocytosis". Cancer Control. 21 (4): 328–34. PMID 25310214.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Langerhans cell histiocytosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Langerhans_cell_histiocytosis Accessed on February, 2 2016
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Langerhans cell histiocytosis. Radiopeadia (2015) http://radiopaedia.org/articles/langerhans-cell-histiocytosis Accessed on February, 3 2016