Squamous cell carcinoma of the lung historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2] Maria Fernanda Villarreal, M.D. [3]

Overview

In 1987, researchers first establish that a receptor on cancer cells called the epidermal growth factor receptor (EGFR) plays an important role in the growth and spread of squamous cell carcinoma of the lung.^[1]

In 1879, Harting and Hesse, two German physicians, first described the association between lung cancer and working in mines.^[2]
In 1929, Fritz Lickint a German physican first described the association between smoking and squamous cell carcinoma of the lung.^[3]
In 1950, "The British Doctors Study" was the first solid epidemiological evidence of the link between lung cancer and smoking.^[4]
In 1966, the first preventive measures against lung cancer were implemented, warning labels first appear on cigarette packs "Caution: Cigarette Smoking May Be Hazardous to Your Health".^[5]
In 1982, Geoffrey Cooper, an American pathologist first used the NIH 3T3 focus assay to identify the activated K-ras oncogene in lung cancer cell lines.^[6]
In 1986, the association between second-hand smoking and squamous cell carcinoma of the lung is established.^[5]
In 1987, researchers first establish that a receptor on cancer cells called the epidermal growth factor receptor (EGFR) plays an important role in the growth and spread of squamous cell carcinoma of the lung.^[1]

↑ ^1.0 ^1.1 Timeline of lung cancer. http://cancerprogress.net/timeline/lung-cancer Accessed on February 17, 2016
↑ Greenberg M, Selikoff IJ (1993). "Lung cancer in the Schneeberg mines: a reappraisal of the data reported by Harting and Hesse in 1879". Ann Occup Hyg. 37 (1): 5–14. PMID 8460878.
↑ Fritz Lickint. Wikipedia https://en.wikipedia.org/wiki/Fritz_Lickint Accessed on February 19,2016
↑ Miller YE (2005). "Pathogenesis of lung cancer: 100 year report". Am. J. Respir. Cell Mol. Biol. 33 (3): 216–23. doi:10.1165/rcmb.2005-0158OE. PMC 2715312. PMID 16107574.
↑ ^5.0 ^5.1 Witschi H (2001). "A short history of lung cancer". Toxicol. Sci. 64 (1): 4–6. PMID 11606795.
↑ Der CJ, Krontiris TG, Cooper GM (1982). "Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses". Proc. Natl. Acad. Sci. U.S.A. 79 (11): 3637–40. PMC 346478. PMID 6285355.