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| __NOTOC__
| | #REDIRECT [[Nifedipine#Adult Indications and Dosage]] |
| {{Nifedipine}}
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| {{CMG}}; {{AE}}: {{AK}}
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| '''''For patient information about Nifedipine, click [[Nifedipine (patient information)|here]].'''''
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| ==INDICATIONS AND USAGE==
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| ===Vasospastic Angina===
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| Nifedipine is indicated for the management of [[vasospastic angina]] confirmed by any of the following criteria: 1) classical pattern of angina at rest accompanied by [[ST segment elevation]], 2) angina or coronary artery spasm provoked by [[ergonovine]], or 3) angiographically demonstrated coronary artery spasm. In those patients who have had [[angiography]], the presence of significant fixed obstructive disease is not incompatible with the diagnosis of vasospastic angina, provided that the above criteria are satisfied. Nifedipine may also be used where the clinical presentation suggests a possible vasospastic component but where vasospasm has not been confirmed, e.g., where pain has a variable threshold on exertion or in[[unstable angina]] where electrocardiographic findings are compatible with intermittent vasospasm, or when angina is refractory to [[nitrates]]and/or adequate doses of[[ beta blockers]].
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| ===Chronic Stable Angina (Classical Effort-Associated Angina)===
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| Nifedipine is indicated for the management of [[chronic stable angina]] (effort-associated angina) without evidence of vasospasm in patients who remain symptomatic despite adequate doses of [[beta blockers]] and/or [[organic nitrates]] or who cannot tolerate those agents.
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| In chronic stable angina (effort-associated angina) nifedipine has been effective in controlled trials of up to eight weeks duration in reducing angina frequency and increasing exercise tolerance, but confirmation of sustained effectiveness and evaluation of long-term safety in these patients is incomplete.
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| Controlled studies in small numbers of patients suggest concomitant use of nifedipine and beta-blocking agents may be beneficial in patients with chronic stable angina, but available information is not sufficient to predict with confidence the effects of concurrent treatment, especially in patients with compromised left ventricular function or cardiac conduction abnormalities. When introducing such concomitant therapy, care must be taken to monitor blood pressure closely since severe hypotension can occur from the combined effects of the drugs. (See [[Nifedipine warnings|WARNINGS]].)
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| ===Hypertension===
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| Nifedipine extended-release tablets are indicated for the treatment of [[hypertension]]. They may be used alone or in combination with other antihypertensive agents.
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| ==References==
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| {{Reflist|2}}
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| http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=03be089c-07e5-4f94-bfcc-c6101b311785
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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