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Revision as of 14:02, 30 June 2014

Rosuvastatin
CRESTOR^® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
Clinical Studies
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Rosuvastatin
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

For patient information about Rosuvastatin, click here.

Synonyms / Brand Names: CRESTOR^®

Overview

Rosuvastatin is a member of the drug class of statins, used to treat hypercholesterolemia and related conditions, and to prevent cardiovascular disease. It is currently being marketed by the pharmaceutical company AstraZeneca as Crestor.

FDA Package Insert

Mechanism of Action

CRESTOR is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3‑hydroxy‑3‑methylglutaryl coenzyme A to mevalonate, a precursor of cholesterol. In vivo studies in animals, and in vitro studies in cultured animal and human cells have shown rosuvastatin to have a high uptake into, and selectivity for, action in the liver, the target organ for cholesterol lowering. In in vivo and in vitro studies, rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell-surface to enhance uptake and catabolism of LDL. Second, rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.

Interaction with Alcohol

CRESTOR should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of chronic liver disease.Chronic alcohol liver disease is known to increase rosuvastatin exposure.

References

Template:Statins

@@ Line 1: / Line 1: @@
 __NOTOC__
-{{Gemfibrozil}}
+{{Rosuvastatin}}
-{{CMG}}; {{AE}} {{SS}}
+{{CMG}}; {{AE}}
-'''''For patient information about Gemfibrozil, click [[Gemfibrozil (patient information)|here]].'''''
+'''''For patient information about Rosuvastatin, click [[Rosuvastatin (patient information)|here]].'''''
-{{SB}} LOPID<sup>®</sup>,generic
+{{SB}} CRESTOR<sup>®</sup>
 ==Overview==
-'''Gemfibrozil''' is the [[International Nonproprietary Name|generic name]] for an oral drug used to lower [[lipid]] levels. It belongs to a group of drugs known as [[fibrates]].  It is most commonly sold as the brand name, '''Lopid'''.
+'''Rosuvastatin''' is a member of the [[medication|drug]] class of [[statin]]s, used to treat [[hypercholesterolemia]] and related conditions, and to prevent [[cardiovascular disease]]. It is currently being marketed by the [[pharmaceutical company]] [[AstraZeneca]] as '''Crestor'''.
+==Category==
-==Category==
+Statins,Diols,Carboxylic acids,Sulfonamides,Pyrimidines,Organofluorides,Cardiovasular drugs.
-Cardiovascular Drug,Phenol ethers,Fibrates，Lipid modifying agents
 ==FDA Package Insert==
+'''  [[Rosuvastatin indications and usage|Indications and Usage]]'''
-'''  [[Gemfibrozil indications and usage|Indications and Usage]]'''
+'''| [[Rosuvastatin dosage and administration|Dosage and Administration]]'''
-'''| [[Gemfibrozil dosage and administration|Dosage and Administration]]'''
+'''| [[Rosuvastatin dosage forms and strengths|Dosage Forms and Strengths]]'''
-'''| [[Gemfibrozil contraindications|Contraindications]]'''
+'''| [[Rosuvastatin contraindications|Contraindications]]'''
-'''| [[Gemfibrozil warnings and precautions|Warnings and Precautions]]'''
+'''| [[Rosuvastatin warnings and precautions|Warnings and Precautions]]'''
-'''| [[Gemfibrozil adverse reactions|Adverse Reactions]]'''
+'''| [[Rosuvastatin adverse reactions|Adverse Reactions]]'''
-'''| [[Gemfibrozil drug interactions|Drug Interactions]]'''
+'''| [[Rosuvastatin drug interactions|Drug Interactions]]'''
-'''| [[Gemfibrozil use in specific populations|Use in Specific Populations]]'''
+'''| [[Rosuvastatin use in specific populations|Use in Specific Populations]]'''
-'''| [[Gemfibrozil overdosage|Overdosage]]'''
+'''| [[Rosuvastatin overdosage|Overdosage]]'''
-'''| [[Gemfibrozil description|Description]]'''
+'''| [[Rosuvastatin description|Description]]'''
-'''| [[Gemfibrozil clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[Rosuvastatin clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[Gemfibrozil nonclinical toxicology|Nonclinical Toxicology]]'''
+'''| [[Rosuvastatin nonclinical toxicology|Nonclinical Toxicology]]'''
-'''| [[Gemfibrozil how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[Rosuvastatin clinical studies|Clinical Studies]]'''
-'''| [[Gemfibrozil labels and packages|Labels and Packages]]'''
+'''| [[Rosuvastatin how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[Rosuvastatin patient counseling information|Patient Counseling Information]]'''
+'''| [[Rosuvastatin labels and packages|Labels and Packages]]'''
 ==Mechanism of Action==
-The mechanism of action of gemfibrozil has not been definitely established. In man, LOPID has been shown to inhibit peripheral lipolysis and to decrease the hepatic extraction of free fatty acids, thus reducing hepatic [[triglyceride]] production. LOPID inhibits synthesis and increases clearance of VLDL carrier [[apolipoprotein B]], leading to a decrease in [[VLDL]] production.
+CRESTOR is a selective and competitive inhibitor of [[HMG-CoA]] reductase, the rate-limiting enzyme that converts 3‑hydroxy‑3‑methylglutaryl coenzyme A to mevalonate, a precursor of [[cholesterol]]. In vivo studies in animals, and in vitro studies in cultured animal and human cells have shown rosuvastatin to have a high uptake into, and selectivity for, action in the liver, the target organ for [[cholesterol]] lowering. In in vivo and in vitro studies, rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell-surface to enhance uptake and catabolism of LDL. Second, rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.
+==Interaction with Alcohol==
+CRESTOR should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of chronic liver disease.Chronic alcohol liver disease is known to increase rosuvastatin exposure.
 ==References==
+{{Reflist|2}}
-{{Reflist|2}}
+{{Statins}}
-{{Lipid modifying agents}}
-[[Category:Fibrates]]
+[[Category:Statins]]
-[[Category:Phenol ethers]]
+[[Category:AstraZeneca]]
-[[Category:Cardiovascular Drug]]
+[[Category:Carboxylic acids]]
-[[Category:Drug]]
+[[Category:Sulfonamides]]
+[[Category:Pyrimidines]]
+[[Category:Organofluorides]]
+[[Category:Cardiovasular drugs]]
+[[Category:Drugs]]