Oxolinic acid: Difference between revisions

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(Created page with "{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 384087896 | IUPAC_name = 5-Ethyl-8-oxo-5,8-dihydro[1,3]dioxolo[4,5-''g'']quinoline- 7-carboxyl...")
 
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| molecular_weight = 261.23 g/mol
| molecular_weight = 261.23 g/mol
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__NOTOC__
==Overview==


'''Oxolinic acid''' is a [[quinolone]] [[antibiotic]] developed in Japan in the 1970s.<ref>JP Patent 49138244</ref><ref name="pmid384788">{{cite journal |author=Gleckman R, Alvarez S, Joubert DW, Matthews SJ |title=Drug therapy reviews: oxolinic acid |journal=American Journal of Hospital Pharmacy |volume=36 |issue=8 |pages=1077–9 |year=1979 |month=August |pmid=384788 |doi= |url= }}</ref> Dosages 12–20&nbsp;mg/kg orally administered for five to ten days.  The antibiotic works by inhibiting the enzyme [[DNA gyrase]]. It also acts as a [[dopamine reuptake inhibitor]] and has stimulant effects in mice.<ref name="pmid9928913">{{cite journal |author=Garcia de Mateos-Verchere J, Vaugeois JM, Naudin B, Costentin J |title=Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor |journal=European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology |volume=8 |issue=4 |pages=255–9 |year=1998 |month=December |pmid=9928913 |doi= 10.1016/S0924-977X(97)00083-7|url=http://linkinghub.elsevier.com/retrieve/pii/S0924-977X(97)00083-7}}</ref>
'''Oxolinic acid''' is a [[quinolone]] [[antibiotic]] developed in Japan in the 1970s.<ref>JP Patent 49138244</ref><ref name="pmid384788">{{cite journal |author=Gleckman R, Alvarez S, Joubert DW, Matthews SJ |title=Drug therapy reviews: oxolinic acid |journal=American Journal of Hospital Pharmacy |volume=36 |issue=8 |pages=1077–9 |year=1979 |month=August |pmid=384788 |doi= |url= }}</ref> Dosages 12–20&nbsp;mg/kg orally administered for five to ten days.  The antibiotic works by inhibiting the enzyme [[DNA gyrase]]. It also acts as a [[dopamine reuptake inhibitor]] and has stimulant effects in mice.<ref name="pmid9928913">{{cite journal |author=Garcia de Mateos-Verchere J, Vaugeois JM, Naudin B, Costentin J |title=Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor |journal=European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology |volume=8 |issue=4 |pages=255–9 |year=1998 |month=December |pmid=9928913 |doi= 10.1016/S0924-977X(97)00083-7|url=http://linkinghub.elsevier.com/retrieve/pii/S0924-977X(97)00083-7}}</ref>
==Category==
==Brand Names==


==See also==
==See also==

Revision as of 01:53, 9 January 2014

Oxolinic acid
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
UNII
KEGG
ChEMBL
E number{{#property:P628}}
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Chemical and physical data
FormulaC13H11NO5
Molar mass261.23 g/mol
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Overview

Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s.[1][2] Dosages 12–20 mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.[3]

Category

Brand Names

See also

References

  1. ↑ JP Patent 49138244
  2. ↑ Gleckman R, Alvarez S, Joubert DW, Matthews SJ (1979). "Drug therapy reviews: oxolinic acid". American Journal of Hospital Pharmacy. 36 (8): 1077–9. PMID 384788. Unknown parameter |month= ignored (help)
  3. ↑ Garcia de Mateos-Verchere J, Vaugeois JM, Naudin B, Costentin J (1998). "Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor". European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 8 (4): 255–9. doi:10.1016/S0924-977X(97)00083-7. PMID 9928913. Unknown parameter |month= ignored (help)

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