Oxolinic acid

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Oxolinic acid
Oxolinic acid.png
Clinical data
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E number{{#property:P628}}
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Chemical and physical data
FormulaC13H11NO5
Molar mass261.23 g/mol
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s.[1][2] Dosages 12–20 mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.[3]

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References

  1. JP Patent 49138244
  2. Gleckman R, Alvarez S, Joubert DW, Matthews SJ (1979). "Drug therapy reviews: oxolinic acid". American Journal of Hospital Pharmacy. 36 (8): 1077–9. PMID 384788. Unknown parameter |month= ignored (help)
  3. Garcia de Mateos-Verchere J, Vaugeois JM, Naudin B, Costentin J (1998). "Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor". European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 8 (4): 255–9. doi:10.1016/S0924-977X(97)00083-7. PMID 9928913. Unknown parameter |month= ignored (help)

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