High anion gap metabolic acidosis critical pathways: Difference between revisions
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* Delta-Delta (ΔΔ) = Delta anion gap (ΔAG) / Delta bicarbonate (ΔHCO3) | * Delta-Delta (ΔΔ) = Delta anion gap (ΔAG) / Delta bicarbonate (ΔHCO3) | ||
** Delta anion gap (ΔAG) = Calculated anion gap - Expected anion gap | ** Delta anion gap (ΔAG) = Calculated anion gap - Expected anion gap | ||
*** Calculated anion gap = [Na+] - [Cl-] - [ | *** Calculated anion gap = [Na<sup>+</sup>] - [Cl<sup>-</sup>] - [HCO<sub>3</sub><sup>-</sup>] | ||
*** Expected anion gap = 2.5 x serum albumin level | *** Expected anion gap = 2.5 x serum albumin level | ||
** Delta bicarbonate ( | ** Delta bicarbonate (ΔHCO<sub>3</sub>) = 24 - serum bicarbonate level | ||
==References== | ==References== | ||
Revision as of 01:48, 11 August 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Approach
| metabolic acidosis critical pathways |
| Anion gap | High | Normal | Low |
| Delta-delta (ΔΔ) value | Greater than 2 | Between 1 and 2 | Less than 1 |
Definition
- Delta-Delta value is used to determine whether there is an additional metabolic acid-base disturbance or not.
- Delta-Delta (ΔΔ) = Delta anion gap (ΔAG) / Delta bicarbonate (ΔHCO3)
- Delta anion gap (ΔAG) = Calculated anion gap - Expected anion gap
- Calculated anion gap = [Na+] - [Cl-] - [HCO3-]
- Expected anion gap = 2.5 x serum albumin level
- Delta bicarbonate (ΔHCO3) = 24 - serum bicarbonate level
- Delta anion gap (ΔAG) = Calculated anion gap - Expected anion gap