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Revision as of 17:28, 7 February 2013

WikiDoc Resources for Sarcoma

Articles

Most recent articles on Sarcoma

Most cited articles on Sarcoma

Review articles on Sarcoma

Articles on Sarcoma in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Sarcoma

Images of Sarcoma

Photos of Sarcoma

Podcasts & MP3s on Sarcoma

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Evidence Based Medicine

Cochrane Collaboration on Sarcoma

Bandolier on Sarcoma

TRIP on Sarcoma

Clinical Trials

Ongoing Trials on Sarcoma at Clinical Trials.gov

Trial results on Sarcoma

Clinical Trials on Sarcoma at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Sarcoma

NICE Guidance on Sarcoma

NHS PRODIGY Guidance

FDA on Sarcoma

CDC on Sarcoma

Books

Books on Sarcoma

News

Sarcoma in the news

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Commentary

Blogs on Sarcoma

Definitions

Definitions of Sarcoma

Patient Resources / Community

Patient resources on Sarcoma

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Directions to Hospitals Treating Sarcoma

Risk calculators and risk factors for Sarcoma

Healthcare Provider Resources

Symptoms of Sarcoma

Causes & Risk Factors for Sarcoma

Diagnostic studies for Sarcoma

Treatment of Sarcoma

Continuing Medical Education (CME)

CME Programs on Sarcoma

International

Sarcoma en Espanol

Sarcoma en Francais

Business

Sarcoma in the Marketplace

Patents on Sarcoma

Experimental / Informatics

List of terms related to Sarcoma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

A sarcoma (from the Greek 'sarx' meaning "flesh") is a cancer of the connective or supportive tissue (bone, cartilage, fat, muscle, blood vessels) and soft tissue. This is in contrast to carcinomas, which are of epithelial origin (breast, colon, pancreas, and others).

Classification

Sarcomas are given a number of different names, based on the type of tissue from which they arise. For example, osteosarcoma arises from bone, chondrosarcoma arises from cartilage, and leiomyosarcoma arises from smooth muscle. Sarcomas strike people in all age ranges, but they are very rare, accounting for only 1% of all cases of cancer.[1] Soft tissue sarcomas, such as leiomyosarcoma, chondrosarcoma, and gastrointestinal stromal tumor (GIST), are more common in adults than in children. GIST is the most common form of sarcoma, with approximately 3000-3500 cases per year in the United States.[2] This should be compared with breast cancer, with approximately 200,000 cases per year in North America.[3] Bone sarcomas, such as osteosarcoma and Ewing's sarcoma, are more common in children than in adults. These tumors most commonly strike adolescents and young adults between the ages of 12 and 25. In addition to being named based on the tissue of origin, sarcomas are also assigned a grade, such as low grade or high grade. Low grade sarcomas are usually treated surgically, although sometimes radiation therapy or chemotherapy are used. High grade sarcomas are more frequently treated with chemotherapy. Since these tumors are more likely to undergo metastasis (spreading to distant sites), these tumors are treated more aggressively. Childhood sarcomas are almost always treated with a combination of surgery and chemotherapy, and radiation is frequently used as well. The recognition that childhood sarcomas are sensitive to chemotherapy has dramatically improved the survival of patients. For example, in the era before chemotherapy, long term survival for patients with localized osteosarcoma was only approximately 20%, but now has risen to 60-70%.[4]

Types of sarcoma

(ICD-O codes are provided where available.)

References

  1. Borden EC, Baker LH, Bell RS, Bramwell V, Demetri GD, Eisenberg BL, Fletcher CD, Fletcher JA, Ladanyi M, Meltzer P, O'Sullivan B, Parkinson DR, Pisters PW, Saxman S, Singer S, Sundaram M, van Oosterom AT, Verweij J, Waalen J, Weiss SW, Brennan MF. Soft tissue sarcomas of adults: state of the translational science.Clin Cancer Res. 2003 Jun;9(6):1941-56. Review. PMID 12796356
  2. Tran T, Davila JA, El-Serag HB. The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000. Am J Gastroenterol 2005;100:162-8. PMID 15654796
  3. Smigal C, Jemal A, Ward E, Cokkinides V, Smith R, Howe HL, Thun M. Trends in breast cancer by race and ethnicity: update 2006. CA Cancer J Clin 2006;56:168-83. PMID 16737949
  4. Longhi A, Errani C, De Paolis M, Mercuri M, Bacci G. Primary bone osteosarcoma in the pediatric age: state of the art. Cancer Treat Rev. 2006;32:423-36. PMID 16860938

External links

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