Hypertriglyceridemia omega-3 fatty acids: Difference between revisions

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| bgcolor="Gray" |'''Study Population'''
| bgcolor="Gray" |'''Study Population'''
| bgcolor="Gray" |'''Time period'''
| bgcolor="Gray" |'''Time period'''
| bgcolor="Gray'' |'''Intervention'''
| bgcolor="Gray" |'''Intervention'''
| bgcolor="Gray" |'''Results'''
| bgcolor="Gray" |'''Results'''
| bgcolor="Gray" |'''Conclusions'''
| bgcolor="Gray" |'''Conclusions'''

Revision as of 15:37, 4 October 2011

Template:Hypertriglyceridemia

For full Omega-3 fatty acid drug info click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]

Overview

Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the diet, as well as with niacin, fibrates and statins (three classes of drugs). Increased fish oil intake may substantially lower an individual's triglycerides.[1][2][3].

Trial supportive data

Study name Source & year Study question Study Design Study Population Time period Intervention Results Conclusions
Effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia [4] Heart, 2001 To access the safety and efficacy of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia Double blinded randomized controlled trial 59 patients with CHD, on simvastatin 10-40 mg/d, with serum triglycerides > 2.3 mmol/l 1 year Omacor (84% omega-3 fatty acid) 2 g BD or placebo
  • Decrease in serum triglycerides by 20-30% (p<0.005)
  • Decrease in very low-density lipoprotein (VLDL) cholesterol by 30-40% (p<0.005)

External links

http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184

References

  1. ↑ "Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin".
  2. ↑ Terres W, Beil U, Reimann B, Tiede S, Bleifeld W (1991). "[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study]". Zeitschrift für Kardiologie (in German). 80 (1): 20–4. PMID 2035283.
  3. ↑ "Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles".
  4. ↑ Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA; et al. (2001). "An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia". Heart. 85 (5): 544–8. PMC 1729738. PMID 11303007.


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