Microangiopathic hemolytic anemia laboratory findings: Difference between revisions
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===Blood Tests=== | ===Blood Tests=== | ||
Laboratory findings consistent with the diagnosis of [[microangiopathic hemolytic anemia]] include<ref name="pmid28447417">{{cite journal| author=Kottke-Marchant K| title=Diagnostic approach to microangiopathic hemolytic disorders. | journal=Int J Lab Hematol | year= 2017 | volume= 39 Suppl 1 | issue= | pages= 69-75 | pmid=28447417 | doi=10.1111/ijlh.12671 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28447417 }} </ref>: | Laboratory findings consistent with the diagnosis of [[microangiopathic hemolytic anemia]] include<ref name="pmid28447417">{{cite journal| author=Kottke-Marchant K| title=Diagnostic approach to microangiopathic hemolytic disorders. | journal=Int J Lab Hematol | year= 2017 | volume= 39 Suppl 1 | issue= | pages= 69-75 | pmid=28447417 | doi=10.1111/ijlh.12671 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28447417 }} </ref>: | ||
===Complete Blood Count=== | |||
* Normochromic normocytic [[anemia]] | * Normochromic normocytic [[anemia]] | ||
* [[Thrombocytopenia]] usually significant with [[platelet count]] less than 20,000/μL. | * [[Thrombocytopenia]] usually significant with [[platelet count]] less than 20,000/μL. | ||
| Line 16: | Line 16: | ||
* Raised [[red ce]] distribution width | * Raised [[red ce]] distribution width | ||
* Raised mean [[platelet]] volume | * Raised mean [[platelet]] volume | ||
===Peripheral Blood Smear=== | |||
* As red blood cells travel through these damaged vessels, they are shredded. The result is red cell fragmentation and intravascular hemolysis. Under the microscope, damaged red cells have the appearance of schistocytes. | * As red blood cells travel through these damaged vessels, they are shredded. The result is red cell fragmentation and intravascular hemolysis. Under the microscope, damaged red cells have the appearance of schistocytes. | ||
* [[Automated analyser]]s (the machines that perform routine [[full blood count]]s in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or ''schistocytes''. | * [[Automated analyser]]s (the machines that perform routine [[full blood count]]s in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or ''schistocytes''. | ||
Revision as of 19:30, 21 January 2021
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Microangiopathic hemolytic anemia Microchapters |
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Differentiating Microangiopathic hemolytic anemia from other Diseases |
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Diagnosis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Blood Tests
Laboratory findings consistent with the diagnosis of microangiopathic hemolytic anemia include[1]:
Complete Blood Count
- Normochromic normocytic anemia
- Thrombocytopenia usually significant with platelet count less than 20,000/μL.
- High reticulocyte count
- Raised red ce distribution width
- Raised mean platelet volume
Peripheral Blood Smear
- As red blood cells travel through these damaged vessels, they are shredded. The result is red cell fragmentation and intravascular hemolysis. Under the microscope, damaged red cells have the appearance of schistocytes.
- Automated analysers (the machines that perform routine full blood counts in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or schistocytes.
References
- ↑ Kottke-Marchant K (2017). "Diagnostic approach to microangiopathic hemolytic disorders". Int J Lab Hematol. 39 Suppl 1: 69–75. doi:10.1111/ijlh.12671. PMID 28447417.