Wild-type (senile) amyloidosis laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
* Wild-type (senile) amyloidosis is a diagnosis of exclusion. | |||
* Laboratory tests are conducted to evaluate for the presence or absence AL amyloid protein deposition. | |||
* The absence of AL amyloid provides a strong clue towards the diagnosis of wild-type (senile) amyloidosis. | |||
==='''Cardiac'''=== | |||
*[[Cardiac biomarkers]] are the most important predictors of outcome in amyloidosis. | |||
*They provide a quantitative assessment for [[Heart|cardiac]] damage and wall strain.<ref name="pmid21483018">{{cite journal |vauthors=Merlini G, Seldin DC, Gertz MA |title=Amyloidosis: pathogenesis and new therapeutic options |journal=J. Clin. Oncol. |volume=29 |issue=14 |pages=1924–33 |date=May 2011 |pmid=21483018 |pmc=3138545 |doi=10.1200/JCO.2010.32.2271 |url=}}</ref> | |||
*The [[biomarkers]] include: | |||
:*[[Troponin I]] or [[Troponin T]] | |||
:*BNP and NT-proBNP | |||
==References== | ==References== |
Revision as of 21:29, 17 December 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
- Wild-type (senile) amyloidosis is a diagnosis of exclusion.
- Laboratory tests are conducted to evaluate for the presence or absence AL amyloid protein deposition.
- The absence of AL amyloid provides a strong clue towards the diagnosis of wild-type (senile) amyloidosis.
Cardiac
- Cardiac biomarkers are the most important predictors of outcome in amyloidosis.
- They provide a quantitative assessment for cardiac damage and wall strain.[1]
- The biomarkers include:
- Troponin I or Troponin T
- BNP and NT-proBNP
References
- ↑ Merlini G, Seldin DC, Gertz MA (May 2011). "Amyloidosis: pathogenesis and new therapeutic options". J. Clin. Oncol. 29 (14): 1924–33. doi:10.1200/JCO.2010.32.2271. PMC 3138545. PMID 21483018.