Paget's disease of the breast risk factors: Difference between revisions
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==Risk Factors== | ==Risk Factors== | ||
Common risk factors in the development of Paget's disease of the breast are: | Common risk factors in the development of Paget's disease of the breast are: | ||
*Age | *Gender female > male. | ||
*Age incidence is higher with increase in age. | |||
*Personal history of [[breast cancer]] | *Personal history of [[breast cancer]] | ||
*Family history of breast cancer | *Family history of breast cancer | ||
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*[[Mutation|Genetic mutations]] | *[[Mutation|Genetic mutations]] | ||
**[[BRCA1]] | **[[BRCA1]] | ||
**[[BRCA2]] | **[[BRCA2]] 4-14% of male breast cancer | ||
**[[Klinefelter's syndrome]] in males. | |||
** Mutations in RAD51B, PALB2, CYP17, CHEK2, BRIP1, RAD51C and androgen receptors. | |||
**BRIP1 and RAD51C have not been seen in male patients. | |||
*[[Endocrine]]-related states with [[hyperestrogenism]] such as: | |||
:*[[obesity]] | |||
:* exogenous [[estrogen]] | |||
:*[[testicular dystrophic]] [[lesions]] in males. | |||
*Environmental exposure to radiation, high temperature and electromagnetic fields. | |||
*Sociodemographic factors such as: | |||
:*People of African or Ashkenazi Jewish descent | |||
:*Excessive use of alcohol | |||
==References== | ==References== | ||
Revision as of 17:27, 6 March 2019
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Paget's disease of the breast Microchapters |
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Differentiating Paget's disease of the breast from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Paget's disease of the breast risk factors On the Web |
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American Roentgen Ray Society Images of Paget's disease of the breast risk factors |
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Directions to Hospitals Treating Paget's disease of the breast |
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Risk calculators and risk factors for Paget's disease of the breast risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Common risk factors in the development of Paget's disease of the breast are age, personal history of breast cancer, family history of breast cancer, irradiation, and genetic mutations.
Risk Factors
Common risk factors in the development of Paget's disease of the breast are:
- Gender female > male.
- Age incidence is higher with increase in age.
- Personal history of breast cancer
- Family history of breast cancer
- Irradiation
- Genetic mutations
- BRCA1
- BRCA2 4-14% of male breast cancer
- Klinefelter's syndrome in males.
- Mutations in RAD51B, PALB2, CYP17, CHEK2, BRIP1, RAD51C and androgen receptors.
- BRIP1 and RAD51C have not been seen in male patients.
- Endocrine-related states with hyperestrogenism such as:
- obesity
- exogenous estrogen
- testicular dystrophic lesions in males.
- Environmental exposure to radiation, high temperature and electromagnetic fields.
- Sociodemographic factors such as:
- People of African or Ashkenazi Jewish descent
- Excessive use of alcohol