UBL5: Difference between revisions
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'''Ubiquitin-like protein 5''' is a [[protein]] that in humans is encoded by the ''UBL5'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBL5 ubiquitin-like 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59286| accessdate = }}</ref> | '''Ubiquitin-like protein 5''' is a [[protein]] that in humans is encoded by the ''UBL5'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBL5 ubiquitin-like 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59286| accessdate = }}</ref> | ||
It has been shown that in C. elegans mitochondria treated to lower expression of certain electron transport chain proteins during the L3/L4 stage, its expression levels is higher leading to increased lifespans.<ref>Mitochondrial Stress Signals | It has been shown that in ''[[Caenorhabditis elegans|C. elegans]]'' mitochondria treated to lower [[gene expression|expression]] of certain [[electron transport chain]] proteins during the L3/L4 stage, its expression levels is higher leading to increased lifespans.<ref>Mitochondrial Stress Signals | ||
Revise an Old Aging Theory - DOI 10.1016/j.cell.2010.12.023</ref> | Revise an Old Aging Theory - DOI 10.1016/j.cell.2010.12.023</ref> | ||
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| summary_text = Ubiquitin-like proteins (UBLs) are thought to be reversible modulators of protein function rather than protein degraders like ubiquitin (MIM 191339).[supplied by OMIM]<ref name="entrez" /> | | summary_text = Ubiquitin-like proteins (UBLs) are thought to be reversible modulators of protein function rather than protein degraders like [[ubiquitin]] (MIM 191339).[supplied by OMIM]<ref name="entrez" /> | ||
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Revision as of 08:33, 13 March 2018
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Ubiquitin-like protein 5 is a protein that in humans is encoded by the UBL5 gene.[1]
It has been shown that in C. elegans mitochondria treated to lower expression of certain electron transport chain proteins during the L3/L4 stage, its expression levels is higher leading to increased lifespans.[2]
Ubiquitin-like proteins (UBLs) are thought to be reversible modulators of protein function rather than protein degraders like ubiquitin (MIM 191339).[supplied by OMIM][1]
References
- ↑ 1.0 1.1 "Entrez Gene: UBL5 ubiquitin-like 5".
- ↑ Mitochondrial Stress Signals Revise an Old Aging Theory - DOI 10.1016/j.cell.2010.12.023
Further reading
- Friedman JS, Koop BF, Raymond V, Walter MA (2001). "Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes". Genomics. 71 (2): 252–5. doi:10.1006/geno.2000.6439. PMID 11161819.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kantham L, Kerr-Bayles L, Godde N, et al. (2003). "Beacon interacts with cdc2/cdc28-like kinases". Biochem. Biophys. Res. Commun. 304 (1): 125–9. doi:10.1016/S0006-291X(03)00549-7. PMID 12705895.
- McNally T, Huang Q, Janis RS, et al. (2004). "Structural analysis of UBL5, a novel ubiquitin-like modifier". Protein Sci. 12 (7): 1562–6. doi:10.1110/ps.0382803. PMC 2323916. PMID 12824502.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wilkinson CR, Dittmar GA, Ohi MD, et al. (2005). "Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast". Curr. Biol. 14 (24): 2283–8. doi:10.1016/j.cub.2004.11.058. PMID 15620657.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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