Hemophilia classification: Difference between revisions
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==Classification== | ==Classification== | ||
Hemophilia may be classified as severe, moderate or mild | *Hemophilia can be classified into: | ||
'''1. Hemophilia A:''' A [[recessive]] X-linked genetic disorder involving a lack of functional clotting [[factor VIII]] and representing 80% of hemophilia cases.<br>'''2. Hemophilia B:''' A [[recessive]] X-linked genetic disorder involving a lack of functional clotting [[factor IX]] and comprising approximately 20% of hemophilia cases.<br>'''3. Hemophilia C:''' An [[autosomal]] genetic disorder involving a lack of functional clotting [[factor XI]]. This condition is not completely [[recessive]], as [[heterozygous]] individuals also show increased bleeding. | |||
===Classification based on severity=== | |||
*Hemophilia may be classified as severe, moderate or mild based on the levels of [[factor VIII]] or [[factor IX]].<ref>{{Cite web | title =CDC Hemophilia classification| url =http://www.cdc.gov/ncbddd/hemophilia/diagnosis.html }}</ref> | |||
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Revision as of 20:01, 26 December 2018
Hemophilia Microchapters |
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Hemophilia classification On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Hemophilia may be classified into three subtypes based on the lack of functional clotting factors: hemophilia A , hemophilia B, hemophilia C.
Classification
- Hemophilia can be classified into:
1. Hemophilia A: A recessive X-linked genetic disorder involving a lack of functional clotting factor VIII and representing 80% of hemophilia cases.
2. Hemophilia B: A recessive X-linked genetic disorder involving a lack of functional clotting factor IX and comprising approximately 20% of hemophilia cases.
3. Hemophilia C: An autosomal genetic disorder involving a lack of functional clotting factor XI. This condition is not completely recessive, as heterozygous individuals also show increased bleeding.
Classification based on severity
- Hemophilia may be classified as severe, moderate or mild based on the levels of factor VIII or factor IX.[1]
Severity | Levels of Factor VIII (8)
or IX (9) in the blood |
---|---|
Normal (person who does not have hemophilia) | 50% to 100% |
Mild hemophilia | Greater than 5% but less than 50% |
Moderate hemophilia | 1% to 5% |
Severe hemophilia | Less than 1% |
Adapted from CDC Hemophilia Diagnosis> "CDC Hemophilia Diagnosis". |