Glanzmann's thrombasthenia physical examination: Difference between revisions

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==Overview==
==Overview==


Patients with Glanzmann’s thrombasthenia may be asymptomatic, or they could manifest mucosal bleeding, ecchymoses,petechiae and purpura or current bleeding on physical exam.<ref name="pmid23929305">{{cite journal| author=Nurden AT, Pillois X, Wilcox DA| title=Glanzmann thrombasthenia: state of the art and future directions. | journal=Semin Thromb Hemost | year= 2013 | volume= 39 | issue= 6 | pages= 642-55 | pmid=23929305 | doi=10.1055/s-0033-1353393 | pmc=4011384 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23929305  }}</ref>
Patients with [[Glanzmann's thrombasthenia]] may be [[asymptomatic]], or they could manifest [[mucosal bleeding]], [[ecchymoses]], [[petechiae]] and [[purpura]] or current [[bleeding]] on [[physical exam]].


==Physical examination==
==Physical examination==


=== Appearance of the Patient ===
=== Appearance of the Patient ===
* Patient appears well in the absence of severe hemorrhage  
* Patient appears well in the absence of severe [[hemorrhage]]
* Patient appears ill in the persistent bleeding .  
* Patient appears ill in the persistent [[bleeding]].  


=== Vital Signs ===
=== Vital Signs ===
* may have[[Tachycardia]], depends on the severity of the bleeding.
* May have[[Tachycardia]], depends on the severity of the [[bleeding]]
* may have[[Tachypnea]] depends on severity of the bleeding
* May have[[Tachypnea]] depends on severity of the [[bleeding]]


=== Skin ===
=== Skin ===
Line 26: Line 26:


=== HEENT ===
=== HEENT ===
* Evidence of trauma
* Evidence of [[trauma]]
* pale conjunctiva
* Pale [[conjunctiva]]
* [[Epistaxis]]
* [[Epistaxis]]
* palatal petechiae
* Palatal [[petechiae]]
* gingival or other oral cavity bleeding.
* [[Gingival]] or other [[oral cavity]] [[bleeding]]


=== Neck ===
=== Neck ===
No specific sign.
No specific signs


=== Lungs ===
=== Lungs ===
* commonly normal lung sounds.
* Commonly normal [[lung]] sounds


=== Heart ===
=== Heart ===
* commonly normal heart sounds
* Commonly normal [[heart]] sounds


=== Abdomen ===
=== Abdomen ===
The spleen is usually non palpable.
The [[spleen]] is usually non palpable  


=== Neuromuscular ===
=== Neuromuscular ===
* Patient is usually oriented to persons, place, and time
* Patient is usually oriented to persons, place, and time
* Glasgow coma scale is normally 15 / 15 but may may present loss of consciousness in severe fatal hemorrhage episodes. <ref name="pmid16722529">{{cite journal| author=Nurden AT| title=Glanzmann thrombasthenia. | journal=Orphanet J Rare Dis | year= 2006 | volume= 1 | issue=  | pages= 10 | pmid=16722529 | doi=10.1186/1750-1172-1-10 | pmc=1475837 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16722529  }}</ref>
* Glasgow coma scale is normally 15 / 15 but may may present loss of [[consciousness]] in severe fatal [[hemorrhage]] episodes <ref name="pmid16722529">{{cite journal| author=Nurden AT| title=Glanzmann thrombasthenia. | journal=Orphanet J Rare Dis | year= 2006 | volume= 1 | issue=  | pages= 10 | pmid=16722529 | doi=10.1186/1750-1172-1-10 | pmc=1475837 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16722529  }}</ref>


===Gallery===
===Gallery===

Revision as of 17:42, 10 December 2018

Glanzmann's thrombasthenia

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2], Niyousha Danesh, MD-MPH

Overview

Patients with Glanzmann's thrombasthenia may be asymptomatic, or they could manifest mucosal bleeding, ecchymoses, petechiae and purpura or current bleeding on physical exam.

Physical examination

Appearance of the Patient

  • Patient appears well in the absence of severe hemorrhage
  • Patient appears ill in the persistent bleeding.

Vital Signs

Skin

HEENT

Neck

No specific signs

Lungs

  • Commonly normal lung sounds

Heart

  • Commonly normal heart sounds

Abdomen

The spleen is usually non palpable

Neuromuscular

  • Patient is usually oriented to persons, place, and time
  • Glasgow coma scale is normally 15 / 15 but may may present loss of consciousness in severe fatal hemorrhage episodes [1]

Gallery

Extremities

References

  1. Nurden AT (2006). "Glanzmann thrombasthenia". Orphanet J Rare Dis. 1: 10. doi:10.1186/1750-1172-1-10. PMC 1475837. PMID 16722529.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 "Dermatology Atlas".