Glanzmann's thrombasthenia causes: Difference between revisions
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==Overview== | ==Overview== | ||
Glanzmann's thrombasthenia can be inherited in an [[autosomal]] [[recessive]] manner or acquired as an [[autoimmune disorder]]. | Glanzmann's thrombasthenia can be inherited in an [[autosomal]] [[recessive]] manner or acquired as an [[autoimmune disorder]]. In the hereditary type of [[Glanzmann's thrombasthenia]] GPIIb/IIIa (ITG αIIbβ3) is qualitative or quantitative disorder. The [[autoantibodies]] production is the main cause of acquired [[Glanzmann's thrombasthenia]] It can be produced in the [[Acute lymphoblastic leukemia]], [[Non-Hodgkin lymphoma]], [[Multiple myeloma]], [[Hairy cell leukemia]], [[Myelodysplastic syndrome]], [[Idiopathic thrombocytopenic purpura|Immune thrombocytopenic purpura]] (ITP), [[Pregnancy]], [[Autoimmune disease|Autoimmune diseases]] (eg, [[systemic lupus erythematosus]], [[Immune]] [[thrombocytopenia]]),Anti-thrombotic drugs use , like [[abciximab]], [[eptifibatide]], and [[tirofiban]] which all antagonize αIIbβ3 and [[Platelet transfusions]]. | ||
In the hereditary type of | |||
==Causes== | ==Causes== | ||
In the hereditary type of Glanzmann's thrombasthenia GPIIb/IIIa (ITG αIIbβ3) is qualitative or quantitative | In the hereditary type of [[Glanzmann's thrombasthenia]] GPIIb/IIIa (ITG αIIbβ3) is qualitative or quantitative disorder. The [[autoantibodies]] production is the main cause of acquired [[Glanzmann's thrombasthenia]] It can be produced in the of following conditions: | ||
* [[Acute lymphoblastic leukemia]] | |||
The autoantibodies production is the main cause of acquired Glanzmann's thrombasthenia | * [[Non-Hodgkin lymphoma]] | ||
* | * [[Multiple myeloma]] | ||
* [[Hairy cell leukemia]] | |||
* [[Myelodysplastic syndrome]] | |||
* [[Idiopathic thrombocytopenic purpura|Immune thrombocytopenic purpura]] (ITP) | |||
* [[Pregnancy]] | |||
* [[Autoimmune disease|Autoimmune diseases]] (eg, [[systemic lupus erythematosus]], [[Immune]] [[thrombocytopenia]])<ref name="pmid24979837">{{cite journal| author=Blickstein D, Dardik R, Rosenthal E, Lahav J, Molad Y, Inbal A| title=Acquired thrombasthenia due to inhibitory effect of glycoprotein IIbIIIa autoantibodies. | journal=Isr Med Assoc J | year= 2014 | volume= 16 | issue= 5 | pages= 307-10 | pmid=24979837 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24979837 }}</ref> | |||
* Drugs : Anti-thrombotic drugs use , like [[abciximab]], [[eptifibatide]], and [[tirofiban]] which all antagonize αIIbβ3 | |||
* Autoimmune diseases, | * [[Platelet transfusions]]<ref name="pmid26185478">{{cite journal| author=Solh T, Botsford A, Solh M| title=Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options. | journal=J Blood Med | year= 2015 | volume= 6 | issue= | pages= 219-27 | pmid=26185478 | doi=10.2147/JBM.S71319 | pmc=4501245 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26185478 }}</ref> | ||
* Drugs : | |||
* | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 18:10, 13 November 2018
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Glanzmann's thrombasthenia |
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Differentiating Glanzmann's thrombasthenia from other Diseases |
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Glanzmann's thrombasthenia causes On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Niyousha Danesh, MD-MPH
Overview
Glanzmann's thrombasthenia can be inherited in an autosomal recessive manner or acquired as an autoimmune disorder. In the hereditary type of Glanzmann's thrombasthenia GPIIb/IIIa (ITG αIIbβ3) is qualitative or quantitative disorder. The autoantibodies production is the main cause of acquired Glanzmann's thrombasthenia It can be produced in the Acute lymphoblastic leukemia, Non-Hodgkin lymphoma, Multiple myeloma, Hairy cell leukemia, Myelodysplastic syndrome, Immune thrombocytopenic purpura (ITP), Pregnancy, Autoimmune diseases (eg, systemic lupus erythematosus, Immune thrombocytopenia),Anti-thrombotic drugs use , like abciximab, eptifibatide, and tirofiban which all antagonize αIIbβ3 and Platelet transfusions.
Causes
In the hereditary type of Glanzmann's thrombasthenia GPIIb/IIIa (ITG αIIbβ3) is qualitative or quantitative disorder. The autoantibodies production is the main cause of acquired Glanzmann's thrombasthenia It can be produced in the of following conditions:
- Acute lymphoblastic leukemia
- Non-Hodgkin lymphoma
- Multiple myeloma
- Hairy cell leukemia
- Myelodysplastic syndrome
- Immune thrombocytopenic purpura (ITP)
- Pregnancy
- Autoimmune diseases (eg, systemic lupus erythematosus, Immune thrombocytopenia)[1]
- Drugs : Anti-thrombotic drugs use , like abciximab, eptifibatide, and tirofiban which all antagonize αIIbβ3
- Platelet transfusions[2]
References
- ↑ Blickstein D, Dardik R, Rosenthal E, Lahav J, Molad Y, Inbal A (2014). "Acquired thrombasthenia due to inhibitory effect of glycoprotein IIbIIIa autoantibodies". Isr Med Assoc J. 16 (5): 307–10. PMID 24979837.
- ↑ Solh T, Botsford A, Solh M (2015). "Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options". J Blood Med. 6: 219–27. doi:10.2147/JBM.S71319. PMC 4501245. PMID 26185478.